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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 17 of 17 1 ERP Correlates of Altered Orthographic-Phonological Processing in Dyslexia Varga, Vera; Tóth, Dénes; Amora, Kathleen Kay... In: Front Psychol (2021) BASE Show details 2 Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia Gialluisi, Alessandro; Andlauer, Till,; Mirza-Schreiber, Nazanin; Moll, Kristina; Becker, Jessica; Hoffmann, Per; Ludwig, Kerstin,; Czamara, Darina; Pourcain, Beate St; Honbolygó, Ferenc; Tóth, Dénes; Csépe, Valéria; Huguet, Guillaume; Chaix, Yves; Iannuzzi, Stephanie; Demonet, Jean-Francois; Morris, Andrew,; Hulslander, Jacqueline; Willcutt, Erik,; DeFries, John,; Olson, Richard,; Smith, Shelley,; Pennington, Bruce,; Vaessen, Anniek; Maurer, Urs; Lyytinen, Heikki; Peyrard-Janvid, Myriam; Leppänen, Paavo,; Brandeis, Daniel; Bonte, Milene; Stein, John,; Talcott, Joel,; Fauchereau, Fabien; Wilcke, Arndt; Kirsten, Holger; Müller, Bent; Francks, Clyde; Bourgeron, Thomas; Monaco, Anthony,; Ramus, Franck; Landerl, Karin; Kere, Juha; Scerri, Thomas,; Paracchini, Silvia; Fisher, Simon,; Schumacher, Johannes; Nöthen, Markus,; Müller-Myhsok, Bertram; Schulte-Körne, Gerd In: ISSN: 1359-4184 ; EISSN: 1476-5578 ; Molecular Psychiatry ; https://hal.archives-ouvertes.fr/hal-02976104 ; Molecular Psychiatry, Nature Publishing Group, 2020, &#x27E8;10.1038/s41380-020-00898-x&#x27E9; (2020) Abstract: International audience ; Developmental dyslexia (DD) is a learning disorder affecting the ability to read, with a heritability of 40–60%. A notable part of this heritability remains unexplained, and large genetic studies are warranted to identify new susceptibility genes and clarify the genetic bases of dyslexia. We carried out a genome-wide association study (GWAS) on 2274 dyslexia cases and 6272 controls, testing associations at the single variant, gene, and pathway level, and estimating heritability using single-nucleotide polymorphism (SNP) data. We also calculated polygenic scores (PGSs) based on large-scale GWAS data for different neuropsychiatric disorders and cortical brain measures, educational attainment, and fluid intelligence, testing them for association with dyslexia status in our sample. We observed statistically significant (p < 2.8 × 10−6) enrichment of associations at the gene level, for LOC388780 (20p13; uncharacterized gene), and for VEPH1 (3q25), a gene implicated in brain development. We estimated an SNP-based heritability of 20–25% for DD, and observed significant associations of dyslexia risk with PGSs for attention deficit hyperactivity disorder (at pT = 0.05 in the training GWAS: OR = 1.23[1.16; 1.30] per standard deviation increase; p = 8 × 10−13), bipolar disorder (1.53[1.44; 1.63]; p = 1 × 10−43), schizophrenia (1.36[1.28; 1.45]; p = 4 × 10−22), psychiatric cross-disorder susceptibility (1.23[1.16; 1.30]; p = 3 × 10−12), cortical thickness of the transverse temporal gyrus (0.90[0.86; 0.96]; p = 5 × 10−4), educational attainment (0.86[0.82; 0.91]; p = 2 × 10−7), and intelligence (0.72[0.68; 0.76]; p = 9 × 10−29). This study suggests an important contribution of common genetic variants to dyslexia risk, and novel genomic overlaps with psychiatric conditions like bipolar disorder, schizophrenia, and cross-disorder susceptibility. Moreover, it revealed the presence of shared genetic foundations with a neural correlate previously implicated in dyslexia by neuroimaging evidence. Keyword: [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences URL: https://hal.archives-ouvertes.fr/hal-02976104/file/MolPsy20.pdf https://hal.archives-ouvertes.fr/hal-02976104/document https://doi.org/10.1038/s41380-020-00898-x https://hal.archives-ouvertes.fr/hal-02976104 BASE Hide details 3 Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia Gialluisi, Alessandro; Andlauer, Till,; Mirza-Schreiber, Nazanin... In: ISSN: 2158-3188 ; EISSN: 2158-3188 ; Translational Psychiatry ; https://hal.archives-ouvertes.fr/hal-02158502 ; Translational Psychiatry, Nature Pub. Group, 2019, 9, pp.77. &#x27E8;10.1038/s41398-019-0402-0&#x27E9; (2019) BASE Show details 4 Reproducibility of Brain Responses: High for Speech Perception, Low for Reading Difficulties Leppanen, Paavo H. T.; Nenert, Rodolphe; Honbolygo, Ferenc... In: Scientific Reports (2019) BASE Show details 5 Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia ... Gialluisi, Alessandro; Andlauer, Till F.M.; Mirza-Schreiber, Nazanin. - : ETH Zurich, 2019 BASE Show details 6 Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia Gialluisi, Alessandro; Andlauer, Till F.M.; Mirza-Schreiber, Nazanin... In: Translational Psychiatry, 9 (1) (2019) BASE Show details 7 Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia Gialluisi, Alessandro; Andlauer, Till F. M.; Mirza-schreiber, Nazanin. - 2019 BASE Show details 8 Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia Gialluisi, Alessandro; Andlauer, Till F. M.; Mirza-schreiber, Nazanin. - 2019 BASE Show details 9 Reproducibility of Brain Responses: High for Speech Perception, Low for Reading Difficulties Leppänen, Paavo H. T.; Tóth, Dénes; Honbolygó, Ferenc. - : Nature Publishing Group UK, 2019 BASE Show details 10 Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort Becker, Jessica; Czamara, Darina; Scerri, Tom S. - 2015 BASE Show details 11 Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort Becker, Jessica; Czamara, Darina; Scerri, Tom S.. - 2014 BASE Show details 12 Orthographic depth and its impact on Universal Predictors of Reading: a cross-language investigation Bertrand, Daisy; Vaessen, Anniek; Blomert, Leo. - : Sage, 2014 BASE Show details 13 Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort Becker, Jessica; Czamara, Darina; Scerri, Tom S. - : Nature Publishing Group, 2014 BASE Show details 14 Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort Becker, Jessica; Czamara, Darina; Scerri, Tom S. - 2014 BASE Show details 15 Predictors of developmental dyslexia in European orthographies with varying complexity. Landerl, Karin; Ramus, Franck; Moll, Kristina... In: ISSN: 0021-9630 ; EISSN: 1469-7610 ; Journal of Child Psychology and Psychiatry ; https://hal.archives-ouvertes.fr/hal-00965034 ; Journal of Child Psychology and Psychiatry, Wiley, 2013, 54 (6), pp.686-94. &#x27E8;10.1111/jcpp.12029&#x27E9; (2013) BASE Show details 16 Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort. Becker, Jessica; Czamara, Darina; Scerri, Tom S... In: ISSN: 1018-4813 ; EISSN: 1476-5438 ; European Journal of Human Genetics ; https://hal.archives-ouvertes.fr/hal-00964958 ; European Journal of Human Genetics, Nature Publishing Group, 2013, epub ahead of print. &#x27E8;10.1038/ejhg.2013.199&#x27E9; (2013) BASE Show details 17 Cognitive Development of Fluent Word Reading Does Not Qualitatively Differ Between Transparent and Opaque Orthographies Vaessen, Anniek; Bertrand, Daisy; Toth, Denes... In: ISSN: 0022-0663 ; Journal of Educational Psychology ; https://hal.archives-ouvertes.fr/hal-01440459 ; Journal of Educational Psychology, American Psychological Association, 2010, 102 (4), pp.827-842. &#x27E8;10.1037/a0019465&#x27E9; (2010) BASE Show details

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