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1
Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET
In: Neurology (2021)
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2
Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example
Europa, Eduardo; Iaccarino, Leonardo; Perry, David C. - : eScholarship, University of California, 2020
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3
PPA diagnosis (Europa et al., 2020) ...
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4
PPA diagnosis (Europa et al., 2020) ...
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5
Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example
In: Am J Speech Lang Pathol (2020)
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6
Factors that predict diagnostic stability in neurodegenerative dementia.
In: Journal of neurology, vol 266, iss 8 (2019)
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7
Factors that predict diagnostic stability in neurodegenerative dementia.
In: Journal of neurology, vol 266, iss 8 (2019)
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8
Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia.
In: Alzheimer disease and associated disorders, vol 33, iss 3 (2019)
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9
Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia.
In: Alzheimer disease and associated disorders, vol 33, iss 3 (2019)
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10
Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia
In: Alzheimer Dis Assoc Disord (2019)
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11
Criminal behavior in frontotemporal dementia and Alzheimer disease.
In: JAMA neurology, vol 72, iss 3 (2015)
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12
Criminal behavior in frontotemporal dementia and Alzheimer disease.
In: JAMA neurology, vol 72, iss 3 (2015)
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13
Interrater reliability of the new criteria for behavioral variant frontotemporal dementia.
In: Neurology, vol 80, iss 21 (2013)
Abstract: ObjectiveTo evaluate the interrater reliability of the new International Behavioural Variant FTD Criteria Consortium (FTDC) criteria for behavioral variant frontotemporal dementia (bvFTD).MethodsTwenty standardized clinical case modules were developed for patients with a range of neurodegenerative diagnoses, including bvFTD, primary progressive aphasia (nonfluent, semantic, and logopenic variant), Alzheimer disease, and Lewy body dementia. Eighteen blinded raters reviewed the modules and 1) rated the presence or absence of core diagnostic features for the FTDC criteria, and 2) provided an overall diagnostic rating. Interrater reliability was determined by κ statistics for multiple raters with categorical ratings.ResultsThe mean κ value for diagnostic agreement was 0.81 for possible bvFTD and 0.82 for probable bvFTD ("almost perfect agreement"). Interrater reliability for 4 of the 6 core features had "substantial" agreement (behavioral disinhibition, perseverative/compulsive, sympathy/empathy, hyperorality; κ = 0.61-0.80), whereas 2 had "moderate" agreement (apathy/inertia, neuropsychological; κ = 0.41-0.6). Clinician years of experience did not significantly influence rater accuracy.ConclusionsThe FTDC criteria show promise for improving the diagnostic accuracy and reliability of clinicians and researchers. As disease-altering therapies are developed, accurate differential diagnosis between bvFTD and other neurodegenerative diseases will become increasingly important.
Keyword: 80 and over; Aged; and over; Clinical Sciences; Cognitive Sciences; Female; Frontotemporal Dementia; Humans; Male; Middle Aged; Neurology & Neurosurgery; Neuropsychological Tests; Neurosciences; Observer Variation; Physicians; Psychology; Single-Blind Method
URL: https://escholarship.org/uc/item/7tb3z2zb
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