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Digital Speech Analysis in Progressive Supranuclear Palsy and Corticobasal Syndromes
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In: J Alzheimers Dis (2021)
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Automated analysis of lexical features in Frontotemporal Degeneration
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In: Cortex (2021)
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Automated analysis of natural speech in amyotrophic lateral sclerosis spectrum disorders
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In: Neurology (2020)
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Automated analysis of lexical features in Frontotemporal Degeneration
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In: medRxiv (2020)
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A Longitudinal Study of Speech Production in Primary Progressive Aphasia and Behavioral Variant Frontotemporal Dementia
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In: Brain Lang (2019)
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Linguistic markers in Parkinson’s disease (Smith et al., 2018) ...
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Linguistic markers in Parkinson’s disease (Smith et al., 2018) ...
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Validated automatic speech biomarkers in primary progressive aphasia
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Longitudinal Changes in Semantic Concreteness in Semantic Variant Primary Progressive Aphasia (svPPA)
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Evaluation of Linguistic Markers of Word-Finding Difficulty and Cognition in Parkinson's Disease
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Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia
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Longitudinal decline in speech production in Parkinson's disease spectrum disorders
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Transcranial direct current stimulation for the treatment of primary progressive aphasia: An open-label pilot study
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Dissociation of Quantifiers and Object Nouns in Speech in Focal Neurodegenerative Disease
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Abstract:
Quantifiers such as many and some are thought to depend in part on the conceptual representation of number knowledge, while object nouns such as cookie and boy appear to depend in part on visual feature knowledge associated with object concepts. Further, number knowledge is associated with a frontal-parietal network while object knowledge is related in part to anterior and ventral portions of the temporal lobe. We examined the cognitive and anatomic basis for the spontaneous speech production of quantifiers and object nouns in non-aphasic patients with focal neurodegenerative disease associated with corticobasal syndrome (CBS, n=33), behavioral variant frontotemporal degeneration (bvFTD, n=54), and semantic variant primary progressive aphasia (svPPA, n=19). We recorded a semi-structured speech sample elicited from patients and healthy seniors (n=27) during description of the Cookie Theft scene. We observed a dissociation: CBS and bvFTD were significantly impaired in the production of quantifiers but not object nouns, while svPPA were significantly impaired in the production of object nouns but not quantifiers. MRI analysis revealed that quantifier production deficits in CBS and bvFTD were associated with disease in a frontal-parietal network important for number knowledge, while impaired production of object nouns in all patient groups was related to disease in inferior temporal regions important for representations of visual feature knowledge of objects. These findings imply that partially dissociable representations in semantic memory may underlie different segments of the lexicon.
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Article
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996733/ http://www.ncbi.nlm.nih.gov/pubmed/27301638 https://doi.org/10.1016/j.neuropsychologia.2016.06.013
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Dissociable substrates underlie the production of abstract and concrete nouns
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Deficits in sentence expression in amyotrophic lateral sclerosis
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Differentiating primary progressive aphasias in a brief sample of connected speech
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Grammatical comprehension deficits in non-fluent/agrammatic primary progressive aphasia
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