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Digital Speech Analysis in Progressive Supranuclear Palsy and Corticobasal Syndromes
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In: J Alzheimers Dis (2021)
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Automated analysis of lexical features in Frontotemporal Degeneration
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In: Cortex (2021)
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Automated analysis of natural speech in amyotrophic lateral sclerosis spectrum disorders
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In: Neurology (2020)
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Automated analysis of lexical features in Frontotemporal Degeneration
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In: medRxiv (2020)
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A Longitudinal Study of Speech Production in Primary Progressive Aphasia and Behavioral Variant Frontotemporal Dementia
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In: Brain Lang (2019)
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Linguistic markers in Parkinson’s disease (Smith et al., 2018) ...
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Linguistic markers in Parkinson’s disease (Smith et al., 2018) ...
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Validated automatic speech biomarkers in primary progressive aphasia
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Longitudinal Changes in Semantic Concreteness in Semantic Variant Primary Progressive Aphasia (svPPA)
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Evaluation of Linguistic Markers of Word-Finding Difficulty and Cognition in Parkinson's Disease
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Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia
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Longitudinal decline in speech production in Parkinson's disease spectrum disorders
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Ash, Sharon; Jester, Charles; York, Collin; Kofman, Olga L.; Langey, Rachel; Halpin, Amy; Firn, Kim; Perez, Sophia D.; Chahine, Lama; Spindler, Meredith; Dahodwala, Nabila; Irwin, David J.; McMillan, Corey; Weintraub, Daniel; Grossman, Murray. - 2017
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Abstract:
We examined narrative speech production longitudinally in non-demented (n=15) and mildly demented (n=8) patients with Parkinson's disease spectrum disorder (PDSD), and we related increasing impairment to structural brain changes in specific language and motor regions. Patients provided semi-structured speech samples, describing a standardized picture at two time points (mean±SD interval=38±24 months). The recorded speech samples were analyzed for fluency, grammar, and informativeness. PDSD patients with dementia exhibited significant decline in their speech, unrelated to changes in overall cognitive or motor functioning. Regression analysis in a subset of patients with MRI scans (n=11) revealed that impaired language performance at Time 2 was associated with reduced gray matter (GM) volume at Time 1 in regions of interest important for language functioning but not with reduced GM volume in motor brain areas. These results dissociate language and motor systems and highlight the importance of non-motor brain regions for declining language in PDSD.
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Article
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512868/ http://www.ncbi.nlm.nih.gov/pubmed/28527315 https://doi.org/10.1016/j.bandl.2017.05.001
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Transcranial direct current stimulation for the treatment of primary progressive aphasia: An open-label pilot study
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Dissociation of Quantifiers and Object Nouns in Speech in Focal Neurodegenerative Disease
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Dissociable substrates underlie the production of abstract and concrete nouns
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Deficits in sentence expression in amyotrophic lateral sclerosis
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Differentiating primary progressive aphasias in a brief sample of connected speech
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Grammatical comprehension deficits in non-fluent/agrammatic primary progressive aphasia
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