1 |
Innate immunity impacts social-cognitive functioning in people with multiple sclerosis and healthy individuals: Implications for IL-1ra and urinary immune markers
|
|
|
|
In: Brain Behav Immun Health (2021)
|
|
Abstract:
Social-cognitive difficulties can negatively impact interpersonal communication, shared social experience, and meaningful relationships. This pilot investigation examined the relationship between social-cognitive functioning and inflammatory markers in people with multiple sclerosis (MS) and demographically-matched healthy individuals. Additionally, we compared the immune marker profile in serum and urine-matched samples. Social cognitive functioning was objectively assessed using The Awareness of Social Inference Test – Short (TASIT-S) and subjectively assessed using self-reports of abilities in emotion recognition, emotional empathy, and cognitive theory of mind. In people with MS and healthy individuals, there were moderate-to-large negative relationships between pro-inflammatory biomarkers (serum IL-1β, IL-17, TNF-α, IP-10, MIP-1α, and urine IP-10, MIP-1β) of the innate immune system and social-cognitive functioning. In MS, a higher serum concentration of the anti-inflammatory marker IL-1ra was associated with better social-cognitive functioning (i.e., self-reported emotional empathy and TASIT-S sarcasm detection performance). However, there were mixed findings for anti-inflammatory serum markers IL-4 and IL-10. Overall, our findings indicate a relationship between pro-inflammatory cytokines and social-cognitive abilities. Future studies may provide greater insight into biologically-derived inflammatory processes, sickness behaviour, and their connection with social cognition.
|
|
Keyword:
Full Length Article
|
|
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474509/ http://www.ncbi.nlm.nih.gov/pubmed/34589763 https://doi.org/10.1016/j.bbih.2021.100254
|
|
BASE
|
|
Hide details
|
|
2 |
Discourse recovery after severe traumatic brain injury: exploring the first year
|
|
|
|
In: Brain Inj (2019)
|
|
BASE
|
|
Show details
|
|
3 |
Discourse recovery after severe traumatic brain injury : exploring the first year
|
|
|
|
BASE
|
|
Show details
|
|
4 |
Procedural discourse performance in adults with severe traumatic brain injury at 3 and 6 months post injury
|
|
|
|
In: Brain Inj (2018)
|
|
BASE
|
|
Show details
|
|
5 |
Procedural discourse performance in adults with severe traumatic brain injury at 3 and 6 months post injury
|
|
|
|
BASE
|
|
Show details
|
|
6 |
Cognitive-communication and psychosocial functioning 12 months after severe traumatic brain injury
|
|
|
|
BASE
|
|
Show details
|
|
7 |
Conversational topics discussed by individuals with severe traumatic brain injury and their communication partners during sub-acute recovery
|
|
|
|
In: Brain Inj (2016)
|
|
BASE
|
|
Show details
|
|
8 |
Conversational topics discussed by individuals with severe traumatic brain injury and their communication partners during sub-acute recovery
|
|
|
|
BASE
|
|
Show details
|
|
9 |
The Single-Case Reporting Guideline In BEhavioural Interventions (SCRIBE) 2016 Statement
|
|
|
|
BASE
|
|
Show details
|
|
10 |
The Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement
|
|
|
|
BASE
|
|
Show details
|
|
17 |
The methodological quality of aphasia research: an investigation using the PsycBITE™ database
|
|
|
|
BASE
|
|
Show details
|
|
|
|