1 |
Lesions that do or do not impair digit span: a study of 816 stroke survivors
|
|
|
|
In: Brain Commun (2021)
|
|
BASE
|
|
Show details
|
|
2 |
Damage to Broca’s area does not contribute to long-term speech production outcome after stroke
|
|
|
|
In: Brain (2021)
|
|
BASE
|
|
Show details
|
|
3 |
A Data-Based Approach for Selecting Pre- and Intra-Operative Language Mapping Tasks
|
|
|
|
In: Front Neurosci (2021)
|
|
BASE
|
|
Show details
|
|
4 |
Right hemisphere structural adaptation and changing language skills years after left hemisphere stroke
|
|
|
|
BASE
|
|
Show details
|
|
5 |
Language Control and Lexical Competition in Bilinguals: An Event-Related fMRI Study
|
|
|
|
BASE
|
|
Show details
|
|
6 |
Dissociating the semantic function of two neighbouring subregions in the left lateral anterior temporal lobe
|
|
|
|
BASE
|
|
Show details
|
|
7 |
A Trade-Off between Somatosensory and Auditory Related Brain Activity during Object Naming But Not Reading
|
|
|
|
BASE
|
|
Show details
|
|
8 |
Comparing language outcomes in monolingual and bilingual stroke patients
|
|
|
|
BASE
|
|
Show details
|
|
9 |
Inter- and Intrahemispheric Connectivity Differences When Reading Japanese Kanji and Hiragana
|
|
|
|
BASE
|
|
Show details
|
|
10 |
Dissecting the functional anatomy of auditory word repetition
|
|
|
|
BASE
|
|
Show details
|
|
11 |
The Importance of Premotor Cortex for Supporting Speech Production after Left Capsular-Putaminal Damage
|
|
|
|
Abstract:
The left putamen is known to be important for speech production, but some patients with left putamen damage can produce speech remarkably well. We investigated the neural mechanisms that support this recovery by using a combination of techniques to identify the neural regions and pathways that compensate for loss of the left putamen during speech production. First, we used fMRI to identify the brain regions that were activated during reading aloud and picture naming in a patient with left putamen damage. This revealed that the patient had abnormally high activity in the left premotor cortex. Second, we used dynamic causal modeling of the patient's fMRI data to understand how this premotor activity influenced other speech production regions and whether the same neural pathway was used by our 24 neurologically normal control subjects. Third, we validated the compensatory relationship between putamen and premotor cortex by showing, in the control subjects, that lower connectivity through the putamen increased connectivity through premotor cortex. Finally, in a lesion-deficit analysis, we demonstrate the explanatory power of our fMRI results in new patients who had damage to the left putamen, left premotor cortex, or both. Those with damage to both had worse reading and naming scores. The results of our four-pronged approach therefore have clinical implications for predicting which patients are more or less likely to recover their speech after left putaminal damage.
|
|
Keyword:
Articles
|
|
URL: https://doi.org/10.1523/JNEUROSCI.1954-14.2014 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205556 http://www.ncbi.nlm.nih.gov/pubmed/25339747
|
|
BASE
|
|
Hide details
|
|
12 |
Sensory-to-motor integration during auditory repetition: a combined fMRI and lesion study
|
|
|
|
BASE
|
|
Show details
|
|
14 |
The Angular Gyrus: Multiple Functions and Multiple Subdivisions
|
|
|
|
BASE
|
|
Show details
|
|
15 |
Inter- and Intrahemispheric Connectivity Differences When Reading Japanese Kanji and Hiragana
|
|
|
|
BASE
|
|
Show details
|
|
16 |
Inter- and Intrahemispheric Connectivity Differences When Reading Japanese Kanji and Hiragana
|
|
|
|
BASE
|
|
Show details
|
|
17 |
Auditory–motor interactions for the production of native and non-native speech
|
|
|
|
BASE
|
|
Show details
|
|
19 |
Where, When and Why Brain Activation Differs for Bilinguals and Monolinguals during Picture Naming and Reading Aloud
|
|
|
|
BASE
|
|
Show details
|
|
20 |
Where, When and Why Brain Activation Differs for Bilinguals and Monolinguals during Picture Naming and Reading Aloud
|
|
|
|
BASE
|
|
Show details
|
|
|
|