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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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German Language Adaptation of the NAVS (NAVS-G) and of the NAT (NAT-G): Testing Grammar in Aphasia
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In: Brain Sci (2021)
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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring
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In: Alzheimers Dement (Amst) (2021)
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German language adaptation of the NAVS (NAVS-G) and of the NAT (NAT-G): testing grammar in aphasia
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In: Brain sciences. - 11, 4 (2021) , 474, ISSN: 2076-3425 (2021)
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Data from: ApoE is a correlate of phenotypic heterogeneity in Alzheimer’s disease in a national cohort ...
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium
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In: Alzheimers Dement (2020)
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APOE is a correlate of phenotypic heterogeneity in Alzheimer disease in a national cohort
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In: Neurology (2020)
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Measurement and characterization of distinctive clinical phenotypes using the Frontotemporal Lobar Degeneration Module (FTLD-MOD)
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In: Alzheimers Dement (2020)
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Familial language network vulnerability in primary progressive aphasia
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In: Neurology (2020)
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Montreal Cognitive Assessment (MoCA) Performance and Domain-Specific Index Scores in Amnestic versus Aphasic Dementia
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In: J Int Neuropsychol Soc (2020)
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Genetic screen in a large series of patients with primary progressive aphasia
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PREFERENTIAL DISRUPTION OF AUDITORY WORD REPRESENTATIONS IN PRIMARY PROGRESSIVE APHASIA WITH THE NEUROPATHOLOGY OF FTLD-TDP TYPE A
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Northwestern Anagram Test-Italian (Nat-I) for primary progressive aphasia
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In: Cortex (2019)
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Clinical and cortical decline in the aphasic variant of Alzheimer’s disease
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Neuropathologic basis of in vivo cortical atrophy in the aphasic variant of Alzheimer’s disease
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In: Brain Pathol (2019)
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Word comprehension in temporal cortex and Wernicke area: A PPA perspective
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Mesulam, M.-Marsel; Rader, Benjamin M.; Sridhar, Jaiashre; Nelson, Matthew J.; Hyun, Jungmoon; Rademaker, Alfred; Geula, Changiz; Bigio, Eileen H.; Thompson, Cynthia K.; Gefen, Tamar D.; Weintraub, Sandra; Rogalski, Emily J.. - : Lippincott Williams & Wilkins, 2019
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Abstract:
OBJECTIVE: To explore atrophy–deficit correlations of word comprehension and repetition in temporoparietal cortices encompassing the Wernicke area, based on patients with primary progressive aphasia (PPA). METHODS: Cortical thickness in regions within and outside the classical Wernicke area, measured by FreeSurfer, was correlated with repetition and single word comprehension scores in 73 right-handed patients at mild to moderate stages of PPA. RESULTS: Atrophy in the Wernicke area was correlated with repetition (r = 0.42, p = 0.001) but not single word comprehension (r = −0.072, p = 0.553). Correlations with word comprehension were confined to more anterior parts of the temporal lobe, especially its anterior third (r = 0.60, p < 0.001). A single case with postmortem autopsy illustrated preservation of word comprehension but not repetition 6 months prior to death despite nearly 50% loss of cortical volume and severe neurofibrillary degeneration in core components of the Wernicke area. CONCLUSIONS: Temporoparietal cortices containing the Wernicke area are critical for language repetition. Contrary to the formulations of classic aphasiology, their role in word and sentence comprehension is ancillary rather than critical. Thus, the Wernicke area is not sufficient to sustain word comprehension if the anterior temporal lobe is damaged. Traditional models of the role of the Wernicke area in comprehension are based almost entirely on patients with cerebrovascular lesions. Such lesions also cause deep white matter destruction and acute network diaschisis, whereas progressive neurodegenerative diseases associated with PPA do not. Conceptualizations of the Wernicke area that appear to conflict, therefore, can be reconciled by considering the hodologic and physiologic differences of the underlying lesions.
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340389/ http://www.ncbi.nlm.nih.gov/pubmed/30578374 https://doi.org/10.1212/WNL.0000000000006788
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Morphology and Distribution of TDP-43 Pre-inclusions in Primary Progressive Aphasia
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