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Genome-wide analysis of gene dosage in 24,092 individuals estimates that 10,000 genes modulate cognitive ability
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In: ISSN: 1359-4184 ; EISSN: 1476-5578 ; Molecular Psychiatry ; https://hal-pasteur.archives-ouvertes.fr/pasteur-03325369 ; Molecular Psychiatry, Nature Publishing Group, 2021, ⟨10.1038/s41380-020-00985-z⟩ (2021)
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1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans
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Effect Sizes of Deletions and Duplications on Autism Risk Across the Genome
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In: ISSN: 0002-953X ; EISSN: 1535-7228 ; American Journal of Psychiatry ; https://hal-pasteur.archives-ouvertes.fr/pasteur-03325371 ; American Journal of Psychiatry, American Psychiatric Publishing, 2021, 178 (1), pp.87-98. ⟨10.1176/appi.ajp.2020.19080834⟩ (2021)
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Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis
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Hartwig, Fernando Pires; Davies, Neil Martin; Horta, Bernardo Lessa; Ahluwalia, Tarunveer S.; Bisgaard, Hans; Bønnelykke, Klaus; Caspi, Avshalom; Moffitt, Terrie E.; Poulton, Richie; Sajjad, Ayesha; Tiemeier, Henning W.; Dalmau-Bueno, Albert; Guxens, Mònica; Bustamante, Mariona; Santa-Marina, Loreto; Parker, Nadine; Paus, Tomáš; Pausova, Zdenka; Lauritzen, Lotte; Schnurr, Theresia M.; Michaelsen, Kim F.; Hansen, Torben; Oddy, Wendy; Pennell, Craig E.; Warrington, Nicole M.; Davey Smith, George; Victora, Cesar Gomes. - : Oxford University Press, 2019
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Abstract:
Accumulating evidence suggests that breastfeeding benefits children's intelligence, possibly due to long-chain polyunsaturated fatty acids (LC-PUFAs) present in breast milk. Under a nutritional adequacy hypothesis, an interaction between breastfeeding and genetic variants associated with endogenous LC-PUFAs synthesis might be expected. However, the literature on this topic is controversial.We investigated this gene × environment interaction through a collaborative effort. The primary analysis involved >12 000 individuals and used ever breastfeeding, FADS2 polymorphisms rs174575 and rs1535 coded assuming a recessive effect of the G allele, and intelligence quotient (IQ) in Z scores.There was no strong evidence of interaction, with pooled covariate-adjusted interaction coefficients (i.e. difference between genetic groups of the difference in IQ Z scores comparing ever with never breastfed individuals) of 0.12[(95% confidence interval (CI): -0.19; 0.43] and 0.06 (95% CI: -0.16; 0.27) for the rs174575 and rs1535 variants, respectively. Secondary analyses corroborated these results. In studies with ≥5.85 and
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Keyword:
2713 Epidemiology; Breastfeeding; Effect modification; FADS2; Fatty acids; Intelligence; Meta-analysis
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URL: https://espace.library.uq.edu.au/view/UQ:bb3d8ad
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Novel genetic loci associated with hippocampal volume
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In: ISSN: 2041-1723 ; EISSN: 2041-1723 ; Nature Communications ; https://hal.archives-ouvertes.fr/hal-01488337 ; Nature Communications, Nature Publishing Group, 2017, 8, pp.13624. ⟨10.1038/ncomms13624⟩ (2017)
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Novel genetic loci underlying human intracranial volume identified through genome-wide association
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In: ISSN: 1097-6256 ; EISSN: 1546-1726 ; Nature Neuroscience ; https://hal.archives-ouvertes.fr/hal-01382716 ; Nature Neuroscience, Nature Publishing Group, 2016, 19 (12), pp.1569-1582. ⟨10.1038/nn.4398⟩ (2016)
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ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide
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In: ISSN: 1053-8119 ; EISSN: 1095-9572 ; NeuroImage ; https://hal.archives-ouvertes.fr/hal-01380998 ; NeuroImage, Elsevier, 2015, ⟨10.1016/j.neuroimage.2015.11.057⟩ (2015)
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Common genetic variants influence human subcortical brain structures.
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In: ISSN: 0028-0836 ; EISSN: 1476-4679 ; Nature ; https://hal.archives-ouvertes.fr/hal-01196805 ; Nature, Nature Publishing Group, 2015, 520 (7546), pp.224-9. ⟨10.1038/nature14101⟩ (2015)
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The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
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In: ISSN: 1931-7557 ; EISSN: 1931-7565 ; Brain imaging and behavior (Brain Imaging Behav) ; https://hal-pasteur.archives-ouvertes.fr/pasteur-01967166 ; Brain imaging and behavior (Brain Imaging Behav), Secaucus, NJ : Springer, 2014, 8 (2), pp.152-182. ⟨10.1007/s11682-013-9269-5⟩ (2014)
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