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Promoting Mental Health and Wellbeing in Multicultural Australia: A Collaborative Regional Approach
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In: International Journal of Environmental Research and Public Health; Volume 19; Issue 5; Pages: 2723 (2022)
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EMPIRICAL METHODS OF MODELING SELF-ORGANIZATION OF LEXICAL INNOVATIONS IN THE MENTAL LEXICON ... : ЭМПИРИЧЕСКИЕ МЕТОДЫ МОДЕЛИРОВАНИЯ САМООРГАНИЗАЦИИ ЛЕКСИЧЕСКИХ ИННОВАЦИЙ В МЕНТАЛЬНОМ ЛЕКСИКОНЕ ...
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Mutual Influences of Mother’s and Daughter’s Mental Health on the Closeness of Their Relationship: An Actor–partner Interdependence Model
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In: ETSU Faculty Works (2021)
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Pronouns, variables, and their positions
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In: Aufklärung; Vol. 8 No. 3 (2021): Setembro-Dezembro; p.11-20 ; Aufklärung: revista de filosofia; v. 8 n. 3 (2021): Setembro-Dezembro; p.11-20 ; 2318-9428 (2021)
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Automated Mental Disorders Assessment Using Machine Learning
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Design, Implementation, and Evaluation of a Sport-Focused Mental Health Service Delivery Model Within a Canadian Centre for Mental Health and Sport
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THE SOCIO-COGNITIVE ASPECT OF VERBALIZATION OF JOURNALISTIC DISCOURSE
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In: Studies in Linguistics, Culture, and FLT, Vol 8, Iss 2, Pp 7-18 (2020) (2020)
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Exploring Cognitive Load of Single and Mixed Mental Models Gesture Sets for UAV Navigation
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In: 1st International Workshop on Human-Drone Interaction ; https://hal.archives-ouvertes.fr/hal-02128398 ; 1st International Workshop on Human-Drone Interaction, Ecole Nationale de l'Aviation Civile [ENAC], May 2019, Glasgow, United Kingdom (2019)
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Семантические особенности ментальных глаголов в рамках фреймового метода в английском языке ... : The semantic features of the mental verbs within the frame method in the English language ...
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Επίδραση της σημασιολογικής συνάφειας ενδογλωσσικά και διαγλωσσικά: Πειραματική διερεύνηση σε ελληνογαλλόφωνους ομιλητές ...
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A comprehensive review of computational methods for automatic prediction of schizophrenia with insight into indigenous populations
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A comprehensive review of computational methods for automatic prediction of schizophrenia with insight into indigenous populations
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Developmental social communication deficits in the Shank3 rat model of phelan-mcdermid syndrome and autism spectrum disorder.
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Berg, Elizabeth L; Copping, Nycole A; Rivera, Josef K; Pride, Michael C; Careaga, Milo; Bauman, Melissa D; Berman, Robert F; Lein, Pamela J; Harony-Nicolas, Hala; Buxbaum, Joseph D; Ellegood, Jacob; Lerch, Jason P; Wöhr, Markus; Silverman, Jill L
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In: Autism research : official journal of the International Society for Autism Research, vol 11, iss 4 (2018)
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Abstract:
Mutations in the SHANK3 gene have been discovered in autism spectrum disorder (ASD), and the intellectual disability, Phelan-McDermid Syndrome. This study leveraged a new rat model of Shank3 deficiency to assess complex behavioral phenomena, unique to rats, which display a richer social behavior repertoire than mice. Uniquely detectable emissions of ultrasonic vocalizations (USV) in rats serve as situation-dependent affective signals and accomplish important communicative functions. We report, for the first time, a call and response acoustic playback assay of bidirectional social communication in juvenile Shank3 rats. Interestingly, we found that Shank3-deficient null males did not demonstrate the enhanced social approach behavior typically exhibited following playback of pro-social USV. Concomitantly, we discovered that emission of USV in response to playback was not genotype-dependent and emitted response calls were divergent in meaning. This is the first report of these socially relevant responses using a genetic model of ASD. A comprehensive and empirical analysis of vigorous play during juvenile reciprocal social interactions further revealed fewer bouts and reduced durations of time spent playing by multiple key parameters, including reduced anogenital sniffing and allogrooming. We further discovered that male null Shank3-deficient pups emitted fewer isolation-induced USV than Shank3 wildtype controls. Postnatal whole brain anatomical phenotyping was applied to visualize anatomical substrates that underlie developmental phenotypes. The data presented here lend support for the important role of Shank3 in social communication, the core symptom domain of ASD. By increasing the number of in vivo functional outcome measures, we improved the likelihood for identifying and moving forward with medical interventions. Autism Res 2018, 11: 587-601. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.Lay summaryClinically relevant outcomes are required to demonstrate the utility of therapeutics. We introduce findings in a rat model, and assess the impact of mutations in Shank3, an autism risk gene. We found that males with deficient expression of Shank3 did not demonstrate typical responses in a bi-directional social communication test and that social interaction was lower on key parameters. Outcome measures reported herein extend earlier results in mice and capture responses to acoustic calls, which is analogous to measuring receptive and expressive communication.
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Keyword:
2.1 Biological and endogenous factors; Age Factors; Animal; animal model; Animals; autism; Autism Spectrum Disorder; Basic Behavioral and Social Science; behavior; Behavioral and Social Science; Brain Disorders; Chromosome Deletion; Chromosome Disorders; Chromosomes; Clinical Sciences; Communication; Developmental & Child Psychology; Disease Models; DNA Mutational Analysis; Exploratory Behavior; Gene Deletion; Genetic; Human; Intellectual and Developmental Disabilities; Interpersonal Relations; Male; Mental Health; Models; Nerve Tissue Proteins; neurodevelopment; Neurosciences; Pair 22; Pediatric; Phelan McDermid Syndrome; Phenotype; Play and Playthings; Psychology; Rats; shank; social; Social Behavior; synapse; Vocalization
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URL: https://escholarship.org/uc/item/0gn9h5cf
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A Social Media Based Examination of the Effects of Counseling Recommendations after Student Deaths on College Campuses
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In: Proceedings of the International AAAI Conference on Web and Social Media; Vol. 12 No. 1 (2018): Twelfth International AAAI Conference on Web and Social Media ; 2334-0770 ; 2162-3449 (2018)
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