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Education differentially contributes to cognitive reserve across racial/ethnic groups
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Family Ties and Cognitive Aging in a Multi-ethnic Cohort
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In: J Aging Health (2020)
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Social Network Characteristics and Cognitive Functioning in Ethnically Diverse Older Adults: The Role of Network Size and Composition
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In: Neuropsychology (2019)
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Semantic and lexical features of words dissimilarly affected by non-fluent, logopenic, and semantic primary progressive aphasia
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Novel genetic loci associated with hippocampal volume
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In: ISSN: 2041-1723 ; EISSN: 2041-1723 ; Nature Communications ; https://hal.archives-ouvertes.fr/hal-01488337 ; Nature Communications, Nature Publishing Group, 2017, 8, pp.13624. ⟨10.1038/ncomms13624⟩ (2017)
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Novel genetic loci underlying human intracranial volume identified through genome-wide association
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In: ISSN: 1097-6256 ; EISSN: 1546-1726 ; Nature Neuroscience ; https://hal.archives-ouvertes.fr/hal-01382716 ; Nature Neuroscience, Nature Publishing Group, 2016, 19 (12), pp.1569-1582. ⟨10.1038/nn.4398⟩ (2016)
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Is Residual Memory Variance a Valid Method for Quantifying Cognitive Reserve? A Longitudinal Application
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Different Demographic, Genetic, and Longitudinal Traits in Language versus Memory Alzheimer’s Subgroups
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Abstract:
The study’s objective was to compare demographics, APOE genotypes, and rate of rise over time in functional impairment in neuropsychologically defined language, typical, and memory subgroups of clinical Alzheimer’s disease (AD). 1,368 participants from the National Alzheimer’s Coordinating Center database with a diagnosis of probable AD (CDR 0.5–1.0) were included. A language subgroup (n = 229) was defined as having language performance >1 SD worse than memory performance. A memory subgroup (n = 213) was defined as having memory performance >1 SD worse than language performance. A typical subgroup (n = 926) was defined as having a difference in language and memory performance of <1 SD. Compared with the memory subgroup, the language subgroup was 3.7 years older and more frequently self-identified as African American (OR = 3.69). Under a dominant genetic model, the language subgroup had smaller odds of carrying at least one APOEε4 allele relative to the memory subgroup. While this difference was present for all ages, it was more striking at a younger age (OR = 0.19 for youngest tertile; OR = 0.52 for oldest tertile). Compared with the memory subgroup, the language subgroup rose 35% faster on the Functional Assessment Questionnaire and 44% faster on CDR sum of boxes over time. Among a subset of participants who underwent autopsy (n = 98), the language, memory, and typical subgroups were equally likely to have an AD pathologic diagnosis, suggesting that variation in non-AD pathologies across subtypes did not lead to the observed differences. The study demonstrates that a language subgroup of AD has different demographics, genetic profile, and disease course in addition to cognitive phenotype.
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Keyword:
Article
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877683
https://doi.org/10.3233/JAD-130320
http://www.ncbi.nlm.nih.gov/pubmed/23788008
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| 9 |
Do Neuropsychological Tests Have the Same Meaning in Spanish Speakers as They Do in English Speakers?
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Examining the Multifactorial Nature of Cognitive Aging with Covariance Analysis of Positron Emission Tomography Data
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Examining the multifactorial nature of cognitive aging with covariance analysis of PET data
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