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Resting-State Functional Connectivity following Phonological Component Analysis: The Combined Action of Phonology and Visual Orthographic Cues
In: ISSN: 2076-3425 ; Brain Sciences ; https://hal.uca.fr/hal-03474243 ; Brain Sciences, MDPI, 2021, 11, pp.1458. ⟨10.3390/brainsci11111458⟩ (2021)
Abstract: International audience ; Anomia is the most frequent and pervasive symptom for people with aphasia (PWA). Phonological component analysis (PCA) is a therapy incorporating phonological cues to treat anomia. Investigations of neural correlates supporting improvements following PCA remain scarce. Resting-state functional connectivity (rsFC) as a marker of therapy-induced neuroplasticity has been reported by our team. The present study explores the efficacy of PCA in French and associated therapy-induced neuroplasticity using whole-brain rsFC analysis. Ten PWA participated in a pre-/post-PCA fMRI study with cognitive linguistic assessments. PCA was delivered in French following the standard procedure. PCA led to significant improvement with trained and untrained items. PCA also led to changes in rsFC between distributed ROIs in the semantic network, visual network, and sub-cortical areas. Changes in rsFC can be interpreted within the frame of the visual and phonological natureof PCA. Behavioral and rsFC data changes associated with PCA in French highlight its efficacy and point to the importance of phonological and orthographic cues to consolidate the word-retrieval strategy, contributing to generalization to untrained words.
Keyword: [SCCO.NEUR]Cognitive science/Neuroscience; anomia; aphasia; resting-state fMRI; therapy
URL: https://hal.uca.fr/hal-03474243/document
https://hal.uca.fr/hal-03474243
https://hal.uca.fr/hal-03474243/file/brainsci-11-01458-v3.pdf
https://doi.org/10.3390/brainsci11111458
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Resting-State Functional Connectivity following Phonological Component Analysis: The Combined Action of Phonology and Visual Orthographic Cues
In: Brain Sci (2021)
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