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Lesion-site-dependent responses to therapy after aphasic stroke
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Less is more: neural mechanisms underlying anomia treatment in chronic aphasic patients.
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Auditory training changes temporal lobe connectivity in ‘Wernicke’s aphasia’: a randomised trial
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Four functionally distinct regions in the left supramarginal gyrus support word processing
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Why the left posterior inferior temporal lobe is needed for word finding
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In: BRAIN , 139 pp. 2823-2826. (2016) (2016)
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Four Functionally Distinct Regions in the Left Supramarginal Gyrus Support Word Processing
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In: CEREBRAL CORTEX , 26 (11) pp. 4212-4226. (2016) (2016)
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Comparing language outcomes in monolingual and bilingual stroke patients.
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Hope, TM; Parker Jones, '; Grogan, A; Crinion, J; Rae, J; Ruffle, L; Leff, AP; Seghier, ML; Price, CJ; Green, DW
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In: Brain , 138 (Pt 4) 1070 - 1083. (2015) (2015)
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Abstract:
Post-stroke prognoses are usually inductive, generalizing trends learned from one group of patients, whose outcomes are known, to make predictions for new patients. Research into the recovery of language function is almost exclusively focused on monolingual stroke patients, but bilingualism is the norm in many parts of the world. If bilingual language recruits qualitatively different networks in the brain, prognostic models developed for monolinguals might not generalize well to bilingual stroke patients. Here, we sought to establish how applicable post-stroke prognostic models, trained with monolingual patient data, are to bilingual stroke patients who had been ordinarily resident in the UK for many years. We used an algorithm to extract binary lesion images for each stroke patient, and assessed their language with a standard tool. We used feature selection and cross-validation to find 'good' prognostic models for each of 22 different language skills, using monolingual data only (174 patients; 112 males and 62 females; age at stroke: mean = 53.0 years, standard deviation = 12.2 years, range = 17.2-80.1 years; time post-stroke: mean = 55.6 months, standard deviation = 62.6 months, range = 3.1-431.9 months), then made predictions for both monolinguals and bilinguals (33 patients; 18 males and 15 females; age at stroke: mean = 49.0 years, standard deviation = 13.2 years, range = 23.1-77.0 years; time post-stroke: mean = 49.2 months, standard deviation = 55.8 months, range = 3.9-219.9 months) separately, after training with monolingual data only. We measured group differences by comparing prediction error distributions, and used a Bayesian test to search for group differences in terms of lesion-deficit associations in the brain. Our models distinguish better outcomes from worse outcomes equally well within each group, but tended to be over-optimistic when predicting bilingual language outcomes: our bilingual patients tended to have poorer language skills than expected, based on trends learned from monolingual data alone, and this was significant (P < 0.05, corrected for multiple comparisons) in 13/22 language tasks. Both patient groups appeared to be sensitive to damage in the same sets of regions, though the bilinguals were more sensitive than the monolinguals. media-1vid1 10.1093/brain/awv020_video_abstract awv020_video_abstract.
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Keyword:
aphasia; bilingualism; language; prognosis; stroke
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URL: http://discovery.ucl.ac.uk/1462690/
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A Trade-Off between Somatosensory and Auditory Related Brain Activity during Object Naming But Not Reading.
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In: J Neurosci , 35 (11) 4751 - 4759. (2015) (2015)
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Plasticity of white matter connectivity in phonetics experts
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In: Brain Structure and Function (2015) (In press). (2015)
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Sensory-to-motor integration during auditory repetition: a combined fMRI and lesion study.
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In: Front Hum Neurosci , 8 , Article 24 . (2014) (2014)
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Inter- and intrahemispheric connectivity differences when reading Japanese Kanji and Hiragana.
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In: Cereb Cortex , 24 (6) pp. 1601-1608. (2014) (2014)
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The importance of premotor cortex for supporting speech production after left capsular-putaminal damage.
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In: J Neurosci , 34 (43) 14338 - 14348. (2014) (2014)
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Dissecting the functional anatomy of auditory word repetition.
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In: Front Hum Neurosci , 8 , Article 246 . (2014) (2014)
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Perturbation of the left inferior frontal gyrus triggers adaptive plasticity in the right homologous area during speech production.
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In: Proc Natl Acad Sci U S A , 110 (41) 16402 - 16407. (2013) (2013)
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Functionally distinct contributions of the anterior and posterior putamen during sublexical and lexical reading.
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In: Front Hum Neurosci , 7 , Article 787 . (2013) (2013)
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Predicting outcome and recovery after stroke with lesions extracted from MRI images
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In: NEUROIMAGE-CLINICAL , 2 pp. 424-433. (2013) (2013)
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Lesions impairing regular versus irregular past tense production
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In: NeuroImage: Clinical , 3 438 - 449. (2013) (2013)
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Auditory-motor interactions for the production of speech in native and non-native speech
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In: The Journal of Neuroscience , 33 (6) pp. 2376-2387. (2013) (2013)
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Reading without the left ventral occipito-temporal cortex.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2012)
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