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Lesion-site-dependent responses to therapy after aphasic stroke
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Less is more: neural mechanisms underlying anomia treatment in chronic aphasic patients.
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Auditory training changes temporal lobe connectivity in ‘Wernicke’s aphasia’: a randomised trial
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Four functionally distinct regions in the left supramarginal gyrus support word processing
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Why the left posterior inferior temporal lobe is needed for word finding
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In: BRAIN , 139 pp. 2823-2826. (2016) (2016)
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Four Functionally Distinct Regions in the Left Supramarginal Gyrus Support Word Processing
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In: CEREBRAL CORTEX , 26 (11) pp. 4212-4226. (2016) (2016)
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Comparing language outcomes in monolingual and bilingual stroke patients.
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In: Brain , 138 (Pt 4) 1070 - 1083. (2015) (2015)
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A Trade-Off between Somatosensory and Auditory Related Brain Activity during Object Naming But Not Reading.
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In: J Neurosci , 35 (11) 4751 - 4759. (2015) (2015)
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Plasticity of white matter connectivity in phonetics experts
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In: Brain Structure and Function (2015) (In press). (2015)
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Sensory-to-motor integration during auditory repetition: a combined fMRI and lesion study.
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In: Front Hum Neurosci , 8 , Article 24 . (2014) (2014)
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Inter- and intrahemispheric connectivity differences when reading Japanese Kanji and Hiragana.
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In: Cereb Cortex , 24 (6) pp. 1601-1608. (2014) (2014)
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The importance of premotor cortex for supporting speech production after left capsular-putaminal damage.
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In: J Neurosci , 34 (43) 14338 - 14348. (2014) (2014)
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Abstract:
The left putamen is known to be important for speech production, but some patients with left putamen damage can produce speech remarkably well. We investigated the neural mechanisms that support this recovery by using a combination of techniques to identify the neural regions and pathways that compensate for loss of the left putamen during speech production. First, we used fMRI to identify the brain regions that were activated during reading aloud and picture naming in a patient with left putamen damage. This revealed that the patient had abnormally high activity in the left premotor cortex. Second, we used dynamic causal modeling of the patient's fMRI data to understand how this premotor activity influenced other speech production regions and whether the same neural pathway was used by our 24 neurologically normal control subjects. Third, we validated the compensatory relationship between putamen and premotor cortex by showing, in the control subjects, that lower connectivity through the putamen increased connectivity through premotor cortex. Finally, in a lesion-deficit analysis, we demonstrate the explanatory power of our fMRI results in new patients who had damage to the left putamen, left premotor cortex, or both. Those with damage to both had worse reading and naming scores. The results of our four-pronged approach therefore have clinical implications for predicting which patients are more or less likely to recover their speech after left putaminal damage.
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Keyword:
Adult; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Motor Cortex; Premotor cortex; putamen; reading words; recovery pathways; Speech; subcortical stroke; Young Adult
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URL: http://discovery.ucl.ac.uk/1454205/
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Dissecting the functional anatomy of auditory word repetition.
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In: Front Hum Neurosci , 8 , Article 246 . (2014) (2014)
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Perturbation of the left inferior frontal gyrus triggers adaptive plasticity in the right homologous area during speech production.
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In: Proc Natl Acad Sci U S A , 110 (41) 16402 - 16407. (2013) (2013)
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Functionally distinct contributions of the anterior and posterior putamen during sublexical and lexical reading.
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In: Front Hum Neurosci , 7 , Article 787 . (2013) (2013)
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Predicting outcome and recovery after stroke with lesions extracted from MRI images
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In: NEUROIMAGE-CLINICAL , 2 pp. 424-433. (2013) (2013)
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Lesions impairing regular versus irregular past tense production
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In: NeuroImage: Clinical , 3 438 - 449. (2013) (2013)
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Auditory-motor interactions for the production of speech in native and non-native speech
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In: The Journal of Neuroscience , 33 (6) pp. 2376-2387. (2013) (2013)
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Reading without the left ventral occipito-temporal cortex.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2012)
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