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Diagnosing and managing post-stroke aphasia
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In: Expert Rev Neurother (2020)
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Neuromodulation in post-stroke aphasia treatment
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In: Curr Phys Med Rehabil Rep (2020)
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Cerebellar neuromodulation improves naming in post-stroke aphasia
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In: Brain Commun (2020)
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Right Hemispheric Homologous Language Pathways Negatively Predicts Post-Stroke Naming Recovery
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In: Stroke (2019)
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Leukoaraiosis is independently associated with naming outcome in poststroke aphasia
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Predicting Recovery in Acute Post-stroke Aphasia
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Hillis, Argye E.; Beh, Yuan Ye; Sebastian, Rajani; Breining, Bonnie; Tippett, Donna C.; Wright, Amy; Saxena, Sadhvi; Rorden, Chris; Bonilha, Leonardo; Basilakos, Alexandra; Yourganov, Grigori; Fridriksson, Julius. - 2018
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Abstract:
OBJECTIVE: Many stroke patients show remarkable recovery of language after initial severe impairment, but it is difficult to predict which patients will show good recovery. We aimed to identify patient and lesion characteristics that together predict the best naming outcome in four studies. METHODS: We report two longitudinal studies that identified two variables at onset that were strongly associated with good recovery of naming (the most common residual deficit in aphasia) in the first six months after stroke: damage to left posterior superior temporal gyrus (pSTG) and/or superior longitudinal fasciculus/arcuate fasciculus (SLF/AF) and selective serotonin reuptake inhibitor (SSRI) use. We then tested these variables in two independent cohorts of chronic left hemisphere stroke patients, using chi squared tests and multivariable logistic regression for dichotomous outcomes and t-tests for continuous outcomes. RESULTS: Lesion load in left pSTG and SLF/AF was associated with poorer naming outcome. Preservation of these areas and use of SSRIs were associated with naming recovery, independent of lesion volume, time since stroke, and depression. Patients with damage to these critical areas showed better naming outcome if they took SSRIs for three months after stroke. Those with preservation of these critical areas achieved good recovery of naming regardless of SSRI use. INTERPRETATION: Lesion load in left pSTG and SLF/AF at onset predicts later naming performance. Although based on a small number of patients, our preliminary results suggest outcome might be modulated by SSRIs, but these associations need to be confirmed in a larger randomized controlled trial.
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Article
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URL: https://doi.org/10.1002/ana.25184 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867273/ http://www.ncbi.nlm.nih.gov/pubmed/29451321
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Patterns of Decline in Naming and Semantic Knowledge in Primary Progressive Aphasia
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Cerebellar tDCS: A Novel Approach to Augment Language Treatment Post-stroke
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Recovery of orthographic processing after stroke: A longitudinal fMRI study
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Transcranial Direct Current Stimulation in Post Stroke Aphasia and Primary Progressive Aphasia: Current Knowledge and Future Clinical Applications
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Aphasia or Neglect after Thalamic Stroke: The Various Ways They may be Related to Cortical Hypoperfusion
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Distinct mechanisms and timing of language recovery after stroke
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Patterns of Decline on Language Testing in Primary Progressive Aphasia
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