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Variation in Antibiotic Treatment Failure Outcome Definitions in Randomised Trials and Observational Studies of Antibiotic Prescribing Strategies: A Systematic Review and Narrative Synthesis
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In: Antibiotics; Volume 11; Issue 5; Pages: 627 (2022)
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Abstract:
Antibiotic treatment failure is used as an outcome in randomised trials and observational studies of antibiotic treatment strategies and may comprise different events that indicate failure to achieve a desired clinical response. However, the lack of a universally recognised definition has led to considerable variation in the types of events included. We undertook a systematic review of published studies investigating antibiotic treatment strategies for common uncomplicated infections, aiming to describe variation in terminology and components of the antibiotic treatment failure outcomes. We searched Medline, Embase, and the Cochrane Central Register of Clinical trials for English language studies published between January 2010 and January 2021. The population of interest was ambulatory patients seen in primary care or outpatient settings with respiratory tract (RTI), urinary tract (UTI), or skin and soft tissue infection (SSTI), where different antibiotic prescribing strategies were compared, and the outcome was antibiotic treatment failure. We narratively summarised key features from eligible studies and used frequencies and proportions to describe terminology, components, and time periods used to ascertain antibiotic treatment failure outcomes. Database searches identified 2967 unique records, from which 36 studies met our inclusion criteria. This included 10 randomised controlled trials and 26 observational studies, with 20 studies of RTI, 12 of UTI, 4 of SSTI, and 2 of both RTI and SSTI. We identified three key components of treatment failure definitions: prescription changes, escalation of care, and change in clinical condition. Prescription changes were most popular in studies of UTI, while changes in clinical condition were most common in RTI and SSTI studies. We found substantial variation in the definition of antibiotic treatment failure in included studies, even amongst studies of the same infection subtype and study design. Considerable further work is needed to develop a standardised definition of antibiotic treatment failure in partnership with patients, clinicians, and relevant stakeholders.
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Keyword:
observational study; randomised trial; treatment failure
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URL: https://doi.org/10.3390/antibiotics11050627
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| 2 |
How We Failed in Context: A Text-Mining Approach to Understanding Hotel Service Failures
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In: Sustainability; Volume 14; Issue 5; Pages: 2675 (2022)
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A Combined System Metrics Approach to Cloud Service Reliability Using Artificial Intelligence
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In: Big Data and Cognitive Computing; Volume 6; Issue 1; Pages: 26 (2022)
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| 4 |
Speech therapy for children with learning difficulties in mathematics ; Traitement orthophonique de la difficulté scolaire en mathématiques
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In: https://tel.archives-ouvertes.fr/tel-03478066 ; Education. Université Montpellier, 2021. Français. ⟨NNT : 2021MONTS052⟩ (2021)
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| 5 |
Probabilistic analysis of a multi-state warm standby k-outofn: G system in a series configuration using copula linguists ...
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| 6 |
A DMAIC integrated fuzzy FMEA model: A case study in the automotive industry
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| 7 |
Conflict-Generating Factors of Doctor-Patient Communication in Russian-Language Discursive Practices ; Конфликтогенные факторы общения врача с пациентом в русскоязычных дискурсивных практиках
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| 8 |
Productive failure in medical education: Addressing issues in problem-based learning by improving consolidation
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Portolese, Alisha Erica. - : The University of Sydney, 2021. : Faculty of Arts and Social Sciences, Sydney School of Education and Social Work, 2021
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| 9 |
Productive Failure in Virtual Language Learning for English
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Rahayu, Puji. - : The University of Sydney, 2021. : Faculty of Arts and Social Sciences, Sydney School of Education and Social Work, 2021
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| 10 |
Pragmatic failure revisited: Jaworski’s (1994) study in a new light
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In: Eurasian Journal of Applied Linguistics, Vol 7, Iss 1, Pp 303-315 (2021) (2021)
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| 11 |
Numerical analysis of the behavior of a three-layer honeycomb panel with interlayer defects under action of dynamic load
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In: Structural Mechanics of Engineering Constructions and Buildings, Vol 17, Iss 4, Pp 357-365 (2021) (2021)
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| 12 |
Stitches, Bitches, and Bodies: Textiles and the Twenty-First Century 'Female' Body
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| 13 |
Defining Intelligence Failure: A Puzzled Discourse
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In: Open Access Theses & Dissertations (2021)
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| 14 |
A novel hybrid multi-criteria group decision making approach for failure mode and effect analysis: An essential requirement for sustainable manufacturing
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| 15 |
Service failure and recovery strategy: the case of a China's time-honored restaurant
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| 16 |
What are the minimum requirements to establish proficiency in lung ultrasound training for quantifying B-lines?
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In: PMC (2020)
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| 17 |
Consensus and opinion evolution-based failure mode and effect analysis approach for reliability management in social network and uncertainty contexts
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| 18 |
Fuzzy Model for Risk Assessment of Machinery Failures
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In: Symmetry ; Volume 12 ; Issue 4 (2020)
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| 19 |
An Extension of the Failure Mode and Effect Analysis with Hesitant Fuzzy Sets to Assess the Occupational Hazards in the Construction Industry
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In: International Journal of Environmental Research and Public Health ; Volume 17 ; Issue 4 (2020)
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| 20 |
Optimization and Selection of Maintenance Policies in an Electrical Gas Turbine Generator Based on the Hybrid Reliability-Centered Maintenance (RCM) Model
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In: Processes ; Volume 8 ; Issue 6 (2020)
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