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1	Functional Language Network Connectivity in Children of Women with Epilepsy with Selective Antenatal Antiepileptic Drug Exposure
	Sreedharan, Ruma Madhu; Kesavadas, Chandrasekharan; Aiyappan, Subramonium; Anila, K. M.; Mohan, Amitha C.; Thomas, Sanjeev V.. - : Wolters Kluwer - Medknow, 2020
	Abstract: PURPOSE: Children of women with epilepsy and antenatal antiepileptic drug (AED) exposure have increased risk of language dysfunction. Our objective was to compare language related functional MRI network connectivity (FC) of children with women with epilepsy with antenatal AED exposure (CAED) with that of healthy children (COAED) for delineating functional basis of the language dysfunction. METHODS: CAED under prospective follow up in Kerala Registry of Epilepsy and Pregnancy were consecutively sampled. COAED were identified from volunteers with normal brain MRI. Clinical Evaluation of Language Fundamentals score (CELF) was used to assess language. Functional MRI done using verb generation paradigm to activate language areas and key language network nodes were identified. A multivariate ROI-to-ROI and Seed-to-Voxel based FC was done using the selected seed regions in the language areas located in the right and left hemisphere in all subjects using the CONN functional connectivity toolbox in SPM8 under MATLAB. RESULTS: Strong connectivity was observed within the identified language network between all language nodes bilaterally in CAED compare to controls. The mean connectivity strength of language network (LN) on the left side in CAED was 9.63 ± 4.62 (Mean ± SD) while for COAED it was 6.96 ± 3.67 (p=0.0001). The mean connectivity strength of LN between CAED (4.86 ± 1.07) and COAED (4.32 ±1.2) on the right hemisphere was not statistically significant (p=0.18). CONCLUSION: CAED with impaired language function had significantly increased functional connectivity which may indicate poor differentiation and localization of language centers.
	Keyword: Original Article
	URL: https://doi.org/10.4103/aian.AIAN_402_19 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061501/
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2	Functional Connectivity of Language Regions of Stroke Patients with Expressive Aphasia During Real-Time Functional Magnetic Resonance Imaging Based Neurofeedback
	Sreedharan, Sujesh; Arun, KM; Sylaja, PN. - : Mary Ann Liebert, Inc., publishers, 2019
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3	Novel Face-Name Paired Associate Learning and Famous Face Recognition in Mild Cognitive Impairment: A Neuropsychological and Brain Volumetric Study
	Nanda, Satyan; Mohanan, Nandini; Kumari, Sheela. - : S. Karger AG, 2019
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