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Differential Effects of Speech and Language Therapy and rTMS in Chronic Versus Subacute Post-stroke Aphasia: Results of the NORTHSTAR-CA Trial ...
Zumbansen, Anna; Kneifel, Heike; Lazzouni, Latifa. - : SAGE Journals, 2022
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Differential Effects of Speech and Language Therapy and rTMS in Chronic Versus Subacute Post-stroke Aphasia: Results of the NORTHSTAR-CA Trial ...
Abstract: Background & objectiveContralesional 1-Hz repetitive transcranial magnetic stimulation (rTMS) over the right pars triangularis combined with speech-language therapy (SLT) has shown positive results on the recovery of naming in subacute (5–45 days) post-stroke aphasia. NORTHSTAR-CA is an extension of the previously reported NORTHSTAR trial to chronic aphasia (>6 months post-stroke) designed to compare the effectiveness of the same rTMS protocol in both phases.MethodsSixty-seven patients with left middle cerebral artery infarcts (28 chronic, 39 subacute) were recruited (01-2014 to 07-2019) and randomized to receive rTMS (N = 34) or sham stimulation (N = 33) with SLT for 10 days. Primary outcome variables were Z-score changes in naming, semantic fluency and comprehension tests and adverse event frequency. Intention-to-treat analyses tested between-group effects at days 1 and 30 post-treatment. Chronic and subacute results were compared.ResultsAdverse events were rare, mild, and did not differ between ...
Keyword: 110308 Geriatrics and Gerontology; 110904 Neurology and Neuromuscular Diseases; FOS Clinical medicine; Neuroscience
URL: https://dx.doi.org/10.25384/sage.c.5916961.v1
https://sage.figshare.com/collections/Differential_Effects_of_Speech_and_Language_Therapy_and_rTMS_in_Chronic_Versus_Subacute_Post-stroke_Aphasia_Results_of_the_NORTHSTAR-CA_Trial/5916961/1
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Differential Effects of Speech and Language Therapy and rTMS in Chronic Versus Subacute Post-stroke Aphasia: Results of the NORTHSTAR-CA Trial
In: Neurorehabil Neural Repair (2022)
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