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1
Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network
Abstract: Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.
URL: https://eprints.whiterose.ac.uk/177211/1/1-s2.0-S0169409X21000351-main.pdf
https://eprints.whiterose.ac.uk/177211/
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2
Study of central exclusive [Image: see text] production in proton-proton collisions at [Formula: see text] and 13TeV
In: Eur Phys J C Part Fields (2020)
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3
О чем сигналят нам огни: "взрывной" эффект названий фейерверков ; The Rocket’s Red Glaringly Apparent Intent: The Dazzling Effects of Firework Naming
Батлер, Дж.; Butler, J. O.. - : Издательство Уральского университета, 2018
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4
Search for dark matter produced in association with heavy-flavor quark pairs in proton-proton collisions at [Formula: see text]
Sirunyan, A. M.; Tumasyan, A.; Adam, W.. - : Springer Berlin Heidelberg, 2017
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5
On the Bending Properties of Porcine Mitral, Tricuspid, Aortic, and Pulmonary Valve Leaflets
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6
Utterance-Final Lengthening Is Predictive of Infants' Discrimination of English Accents
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7
Parent or community: where do 20-month-olds exposed to two accents acquire their representation of words?
Delle Luche, C; Butler, J; Goslin, J. - : Netherlands, 2012
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8
Infants’ Discrimination of Familiar and Unfamiliar Accents in Speech
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9
Bias for consonantal information over vocalic information in 30-month-olds: cross-linguistic evidence from French and English.
Butler, J; Nazzi, T; Floccia, C. - : United States, 2009
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10
Regional and foreign accent processing in English: can listeners adapt?
Floccia, C; Ellis, L; Butler, J. - : United States, 2009
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11
Categorization of regional and foreign accent in 5- to 7-year-old British children
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12
Lietuvių kalbos terminų žodynai : Anotuota 1900-2005 m. Bibliografijos rodyklė
Gaivenytė-Butler, J.; Keinys, St.; Noreikaitė, A.. - Vilnius : Lietuvių kalbos institutas, 2008
Institut für Empirische Sprachwissenschaft
UB Frankfurt Linguistik
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13
Bronchiectasis in Alaska Native children and Indigenous children from Central Australia
Valery, Patricia C.; Singleton, R.; Redding, G.. - : Wiley-Blackwell Publishing Asia, 2005
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14
Event generator tunes obtained from underlying event and multiparton scattering measurements.
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