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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 Hits 1 – 20 of 25 1 Clinical Correlates of Alzheimer's Disease Cerebrospinal Fluid Analytes in Primary Progressive Aphasia Norise, Catherine; Ungrady, Molly; Halpin, Amy; Jester, Charles; McMillan, Corey T.; Irwin, David J.; Cousins, Katheryn A.; Grossman, Murray. - : Frontiers Media S.A., 2019 Abstract: Background: While primary progressive aphasia (PPA) is associated with frontotemporal lobar degeneration (FTLD) pathology due to tau or TDP, clinical-pathological studies also demonstrate many cases have Alzheimer's disease (AD) pathology. The logopenic variant of PPA (lvPPA) is most often associated with AD pathology, but this has proven to be the least reliable PPA to diagnose using published clinical criteria. In this study, we used cerebrospinal fluid (CSF) analytes to identify patients with likely AD pathology, and relate phenotypic features of lvPPA to CSF. Methods: We studied 46 PPA patients who had available CSF analytes, including 26 with a clinical diagnosis of lvPPA, 9 with non-fluent/agrammatic variant (naPPA), and 11 with semantic variant (svPPA). We identified patients with likely AD pathology using amyloid-beta 1–42 (Aβ(1−42)) < 192 pg/ml and assessed MRI gray matter atrophy in these patients. Results: We found that 23 (49%) of 46 PPA patients have a low CSF Aβ(1−42) level consistent with AD pathology. Twenty-one (91%) of 23 patients had a lvPPA phenotype, and 18 (79%) of 23 cases with an elevated CSF Aβ(1−42) level did not have a lvPPA phenotype. Patients with a lvPPA phenotype demonstrated GM atrophy in the left lateral temporal lobe, and this was also seen in those with a CSF Aβ(1−42) level < 192 pg/ml. Conclusion: The lvPPA clinical phenotype may be a useful screen for CSF analytes that are a surrogate for likely AD pathology, and may help establish eligibility of these patients for disease-modifying treatment trials. Keyword: Neurology URL: https://doi.org/10.3389/fneur.2019.00485 http://www.ncbi.nlm.nih.gov/pubmed/31133977 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524001/ BASE Hide details 2 A Longitudinal Study of Speech Production in Primary Progressive Aphasia and Behavioral Variant Frontotemporal Dementia Ash, Sharon; Nevler, Naomi; Phillips, Jeffrey... In: Brain Lang (2019) BASE Show details 3 Longitudinal progression of grey matter atrophy in non-amnestic Alzheimer’s disease Phillips, Jeffrey S; Da Re, Fulvio; Irwin, David J... In: Brain (2019) BASE Show details 4 18F-Flortaucipir PET/MRI Correlations in Nonamnestic and Amnestic Variants of Alzheimer Disease Nasrallah, Ilya M.; Chen, Yin Jie; Hsieh, Meng-Kang. - : Society of Nuclear Medicine, 2018 BASE Show details 5 Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia Giannini, Lucia A.A.; Irwin, David J.; McMillan, Corey T.. - : Lippincott Williams & Wilkins, 2017 BASE Show details 6 Tau PET Imaging Predicts Cognition in Atypical Variants of Alzheimer’s Disease Phillips, Jeffrey S.; Das, Sandhitsu R.; McMillan, Corey T.. - 2017 BASE Show details 7 Neocortical Origin and Progression of Grey Matter Atrophy In Non-Amnestic Alzheimer’s Disease Phillips, Jeffrey S.; Re, Fulvio Da; Dratch, Laynie. - 2017 BASE Show details 8 Neural Correlates of Verbal Episodic Memory and Lexical Retrieval in Logopenic Variant Primary Progressive Aphasia Win, Khaing T.; Pluta, John; Yushkevich, Paul. - : Frontiers Media S.A., 2017 BASE Show details 9 Dissociation of Quantifiers and Object Nouns in Speech in Focal Neurodegenerative Disease Ash, Sharon; Ternes, Kylie; Bisbing, Teagan. - 2016 BASE Show details 10 ARTERIAL SPIN LABELING PERFUSION PREDICTS LONGITUDINAL DECLINE IN SEMANTIC VARIANT PRIMARY PROGRESSIVE APHASIA Olm, Christopher A.; Kandel, Benjamin M.; Avants, Brain B.. - 2016 BASE Show details 11 How the brain learns how few are “many”: An fMRI study of the flexibility of quantifier semantics Heim, Stefan; McMillan, Corey T.; Clark, Robin. - 2015 BASE Show details 12 Beyond words: Pragmatic inference in behavioral variant of frontotemporal degeneration Spotorno, Nicola; McMillan, Corey T.; Rascovsky, Katya. - 2015 BASE Show details 13 Processing ambiguity in a linguistic context: decision-making difficulties in non-aphasic patients with behavioral variant frontotemporal degeneration Spotorno, Nicola; Healey, Meghan; McMillan, Corey T.. - : Frontiers Media S.A., 2015 BASE Show details 14 Relating brain anatomy and cognitive ability using a multivariate multimodal framework Cook, Philip A.; McMillan, Corey T.; Avants, Brian B.. - 2014 BASE Show details 15 Deficits in sentence expression in amyotrophic lateral sclerosis Ash, Sharon; Olm, Christopher; Mcmillan, Corey T.. - 2014 BASE Show details 16 The relative contributions of frontal and parietal cortex for generalized quantifier comprehension Olm, Christopher A.; McMillan, Corey T.; Spotorno, Nicola. - : Frontiers Media S.A., 2014 BASE Show details 17 Impairment of script comprehension in Lewy body spectrum disorders Gross, Rachel G.; Camp, Emily; McMillan, Corey T.... In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 125 (2013) 3, 330-343 OLC Linguistik Show details 18 Comparative semantic profiles in semantic dementia and Alzheimer's disease Libon, David J.; Rascovsky, Katya; Powers, John. - : Oxford University Press, 2013 BASE Show details 19 White Matter Disease Correlates with Lexical Retrieval Deficits in Primary Progressive Aphasia Powers, John P.; McMillan, Corey T.; Brun, Caroline C.. - : Frontiers Media S.A., 2013 BASE Show details 20 Sparse canonical correlation analysis relates network-level atrophy to multivariate cognitive measures in a neurodegenerative population Avants, Brian B.; Libon, David J.; Rascovsky, Katya. - 2013 BASE Show details Page: 1 2

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