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1
Sensitive measures of cognition in Mild Cognitive Impairment
In: J Alzheimers Dis (2021)
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2
Longitudinal progression of grey matter atrophy in non-amnestic Alzheimer’s disease
In: Brain (2019)
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3
18F-Flortaucipir PET/MRI Correlations in Nonamnestic and Amnestic Variants of Alzheimer Disease
Abstract: Nonamnestic Alzheimer disease (AD) variants, including posterior cortical atrophy and the logopenic variant of primary progressive aphasia, differ from amnestic AD in distributions of tau aggregates and neurodegeneration. We evaluated whether 18F-flortaucipir (also called 18F-AV-1451) PET, targeting tau aggregates, detects these differences, and we compared the results with MRI measures of gray matter (GM) atrophy. Methods: Five subjects with posterior cortical atrophy, 4 subjects with the logopenic variant of primary progressive aphasia, 6 age-matched patients with AD, and 6 control subjects underwent 18F-flortaucipir PET and MRI. SUV ratios and GM volumes were compared using regional and voxel-based methods. Results: The subgroups showed the expected 18F-flortaucipir–binding patterns. Group effect sizes were generally stronger with 18F-flortaucipir PET than with MRI volumes. There were moderate-to-high correlations between regional GM atrophy and 18F-flortaucipir uptake. 18F-flortaucipir binding and GM atrophy correlated similarly to cognitive test performance. Conclusion: 18F-flortaucipir binding corresponds to the expected neurodegeneration patterns in nonamnestic AD, with potential for earlier detection of pathology than is possible with MRI atrophy measures.
Keyword: Neurology
URL: https://doi.org/10.2967/jnumed.117.194282
http://www.ncbi.nlm.nih.gov/pubmed/28747523
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348438/
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4
Prevalence of Amyloid-β Pathology in Distinct Variants of Primary Progressive Aphasia
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5
Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia: Amyloid-β Pathology in PPA
In: Annals of Neurology. - 84, 5 (2018) , 729-740, ISSN: 0364-5134 (2018)
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6
Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia
Giannini, Lucia A.A.; Irwin, David J.; McMillan, Corey T.. - : Lippincott Williams & Wilkins, 2017
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7
Tau PET Imaging Predicts Cognition in Atypical Variants of Alzheimer’s Disease
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8
Neocortical Origin and Progression of Grey Matter Atrophy In Non-Amnestic Alzheimer’s Disease
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9
Amyloid Imaging in Atypical Presentations of Alzheimer’s Disease
Wolk, David A.. - 2013
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10
Amyloid Imaging in Dementias With Atypical Presentation
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11
Improved Proper Name Recall in Aging after Electrical Stimulation of the Anterior Temporal Lobes
Ross, Lars A.; McCoy, David; Coslett, H. Branch. - : Frontiers Research Foundation, 2011
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12
Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional–executive network function in Alzheimer’s disease
Wolk, David A.; Dickerson, Bradford C.; Weiner, Michael. - : National Academy of Sciences, 2010
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13
Preserved metamemorial ability in patients with mild Alzheimer's disease : shifting response bias
In: Brain and cognition. - San Diego, Calif. [u.a.] : Elsevier Science 66 (2008) 1, 32-39
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14
Increased Responsiveness to Novelty is Associated with Successful Cognitive Aging
In: Journal of cognitive neuroscience. - Cambridge, Mass. : MIT Press Journals 18 (2006) 10, 1759-1773
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15
The role of sensory-motor information in object recognition: Evidence from category-specific visual agnosia
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 94 (2005) 2, 131-146
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16
The role of sensory-motor information in object recognition : evidence from category-specific visual agnosia
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 94 (2005) 2, 131-146
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