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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 6 of 6 1 DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation. Sousa Martins, Joao P; Liu, Xueqing; Oke, Ashwini... In: Journal of cell science, vol 129, iss 6 (2016) BASE Show details 2 DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation. Sousa Martins, Joao P; Liu, Xueqing; Oke, Ashwini; Arora, Ripla; Franciosi, Federica; Viville, Stephan; Laird, Diana J; Fung, Jennifer C; Conti, Marco In: Journal of cell science, vol 129, iss 6 (2016) Abstract: Meiotic progression requires exquisitely coordinated translation of maternal messenger (m)RNA that has accumulated during oocyte growth. A major regulator of this program is the cytoplasmic polyadenylation element binding protein 1 (CPEB1). However, the temporal pattern of translation at different meiotic stages indicates the function of additional RNA binding proteins (RBPs). Here, we report that deleted in azoospermia-like (DAZL) cooperates with CPEB1 to regulate maternal mRNA translation. Using a strategy that monitors ribosome loading onto endogenous mRNAs and a prototypic translation target, we show that ribosome loading is induced in a DAZL- and CPEB1-dependent manner, as the oocyte reenters meiosis. Depletion of the two RBPs from oocytes and mutagenesis of the 3' untranslated regions (UTRs) demonstrate that both RBPs interact with the Tex19.1 3' UTR and cooperate in translation activation of this mRNA. We observed a synergism between DAZL and cytoplasmic polyadenylation elements (CPEs) in the translation pattern of maternal mRNAs when using a genome-wide analysis. Mechanistically, the number of DAZL proteins loaded onto the mRNA and the characteristics of the CPE might define the degree of cooperation between the two RBPs in activating translation and meiotic progression. Keyword: 1.1 Normal biological development and functioning; Animals; Biological Sciences; Contraception/Reproduction; CPEB; DAZL; Developmental; Developmental Biology; Female; Gene Expression Regulation; Genetics; Human Genome; Inbred C57BL; Male; Medical and Health Sciences; Meiosis; Messenger; Mice; mRNA Cleavage and Polyadenylation Factors; Oocyte maturation; Oocytes; Oogenesis; Protein Biosynthesis; RBPs; RNA; RNA-Binding Proteins; Transcription Factors; Translation control URL: https://escholarship.org/uc/item/6n26v7bj BASE Hide details 3 DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation Sousa Martins, Joao P.; Liu, Xueqing; Oke, Ashwini. - : The Company of Biologists Ltd, 2016 BASE Show details 4 What’s in an Error? Development of an Error Taxonomy for Phonological Awareness ... Williamson, Robert; Fung, Jennifer; Annable, Caitlin. - : University of Alberta Libraries, 2013 BASE Show details 5 What’s in an Error? Development of an Error Taxonomy for Phonological Awareness Williamson, Robert; Fung, Jennifer; Annable, Caitlin. - 2013 BASE Show details 6 What’s in an Error? Development of an Error Taxonomy for Phonological Awareness Annable, Caitlin; Fung, Jennifer; Williamson, Robert. - : University of Alberta, 2013 BASE Show details

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