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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 11 of 11 1 Genomic Insights Into the Population History and Biological Adaptation of Southwestern Chinese Hmong–Mien People Liu, Yan; Xie, Jie; Wang, Mengge; Liu, Changhui; Zhu, Jingrong; Zou, Xing; Li, Wenshan; Wang, Lin; Leng, Cuo; Xu, Quyi; Yeh, Hui-Yuan; Wang, Chuan-Chao; Wen, Xiaohong; Liu, Chao; He, Guanglin In: Front Genet (2022) Abstract: Hmong–Mien (HM) -speaking populations, widely distributed in South China, the north of Thailand, Laos, and Vietnam, have experienced different settlement environments, dietary habits, and pathogenic exposure. However, their specific biological adaptation remained largely uncharacterized, which is important in the population evolutionary genetics and Trans-Omics for regional Precision Medicine. Besides, the origin and genetic diversity of HM people and their phylogenetic relationship with surrounding modern and ancient populations are also unknown. Here, we reported genome-wide SNPs in 52 representative Miao people and combined them with 144 HM people from 13 geographically representative populations to characterize the full genetic admixture and adaptive landscape of HM speakers. We found that obvious genetic substructures existed in geographically different HM populations; one localized in the HM clines, and others possessed affinity with Han Chinese. We also identified one new ancestral lineage specifically existed in HM people, which spatially distributed from Sichuan and Guizhou in the north to Thailand in the south. The sharing patterns of the newly identified homogenous ancestry component combined the estimated admixture times via the decay of linkage disequilibrium and haplotype sharing in GLOBETROTTER suggested that the modern HM-speaking populations originated from Southwest China and migrated southward in the historic period, which is consistent with the reconstructed phenomena of linguistic and archeological documents. Additionally, we identified specific adaptive signatures associated with several important human nervous system biological functions. Our pilot work emphasized the importance of anthropologically informed sampling and deeply genetic structure reconstruction via whole-genome sequencing in the next step in the deep Chinese Population Genomic Diversity Project (CPGDP), especially in the regions with rich ethnolinguistic diversity. Keyword: Genetics URL: https://doi.org/10.3389/fgene.2021.815160 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762323/ http://www.ncbi.nlm.nih.gov/pubmed/35047024 BASE Hide details 2 Population genetic analysis of Shaanxi male Han Chinese population reveals genetic differentiation and homogenization of East Asians Li, Luyao; Zou, Xing; Zhang, Guanjun... In: Mol Genet Genomic Med (2020) BASE Show details 3 Genetic diversity and phylogenetic structure of four Tibeto‐Burman‐speaking populations in Tibetan‐Yi corridor revealed by insertion/deletion polymorphisms Zou, Xing; He, Guanglin; Wang, Mengge. - : John Wiley and Sons Inc., 2020 BASE Show details 4 Forensic genetic polymorphisms and population structure of the Guizhou Bouyei people based on 19 X-STR loci ... Ren, Zheng; Jianxin Guo; Guanglin He. - : Taylor & Francis, 2019 BASE Show details 5 Forensic genetic polymorphisms and population structure of the Guizhou Bouyei people based on 19 X-STR loci ... Ren, Zheng; Jianxin Guo; Guanglin He. - : Taylor & Francis, 2019 BASE Show details 6 Genetic diversity and phylogenetic analysis of Chinese Han and Li ethnic populations from Hainan Island by 30 autosomal insertion/deletion polymorphisms ... Liu, Jing; Ziwei Ye; Wang, Zheng. - : Taylor & Francis, 2019 BASE Show details 7 Genetic diversity and phylogenetic analysis of Chinese Han and Li ethnic populations from Hainan Island by 30 autosomal insertion/deletion polymorphisms ... Liu, Jing; Ziwei Ye; Wang, Zheng. - : Taylor & Francis, 2019 BASE Show details 8 Genetic structure and forensic characteristics of Tibeto-Burman-speaking Ü-Tsang and Kham Tibetan Highlanders revealed by 27 Y-chromosomal STRs He, Guanglin; Wang, Zheng; Su, Yongdong. - : Nature Publishing Group UK, 2019 BASE Show details 9 Genetic diversities and phylogenetic analyses of three Chinese main ethnic groups in southwest China: A Y-Chromosomal STR study Chen, Pengyu; He, Guanglin; Zou, Xing. - : Nature Publishing Group UK, 2018 BASE Show details 10 Genetic structure and polymorphisms of Gelao ethnicity residing in southwest china revealed by X-chromosomal genetic markers Chen, Pengyu; He, Guanglin; Zou, Xing. - : Nature Publishing Group UK, 2018 BASE Show details 11 Population Genetic Diversity and Phylogenetic Characteristics for High-Altitude Adaptive Kham Tibetan Revealed by DNATyperTM 19 Amplification System Zou, Xing; Wang, Zheng; He, Guanglin. - : Frontiers Media S.A., 2018 BASE Show details

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