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1
Treatment for Anomia in Bilingual Speakers with Progressive Aphasia
In: Brain Sci (2021)
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2
Familial language network vulnerability in primary progressive aphasia
In: Neurology (2020)
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3
Perturbations of Language Network Connectivity in Primary Progressive Aphasia
In: Cortex (2019)
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4
Challenges in diagnosis of primary progressive aphasia
In: BMJ Case Rep (2019)
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5
Functional connectivity is reduced in early stage primary progressive aphasia when atrophy is not prominent
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6
Semantic interference during object naming in agrammatic and logopenic primary progressive aphasia (PPA)
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 120 (2012) 3, 237-250
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7
Semantic Interference during Object Naming in Agrammatic and Logopenic Primary Progressive Aphasia (PPA)
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8
Neural correlates of covert and overt production of tense and agreement morphology: evidence from fMRI
In: Journal of neurolinguistics. - Orlando, Fla. : Elsevier 24 (2011) 2, 183-201
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9
Neural correlates of covert and overt production of tense and agreement morphology: Evidence from fMRI
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10
Positive Effects of Language Treatment for the Logopenic Variant of Primary Progressive Aphasia
Abstract: Despite considerable recent progress in understanding the underlying neurobiology of primary progressive aphasia (PPA) syndromes, relatively little attention has been directed toward the examination of behavioral interventions that may lessen the pervasive communication problems associated with PPA. In this study, we report on an individual with a behavioral profile and cortical atrophy pattern consistent with the logopenic variant of PPA. At roughly two-and-a-half years post onset, his marked lexical retrieval impairment prompted administration of a semantically based intervention to improve word retrieval. The treatment was designed to improve self-directed efforts to engage the participant’s relatively preserved semantic system in order to facilitate word retrieval. His positive response to an intensive (2-week) dose of behavioral treatment was associated with improved lexical retrieval of items within trained categories, and generalized improvement for naming of untrained items that lasted over a 6-month follow-up interval. These findings support the potential value of intensive training to achieve self-directed strategic compensation for lexical retrieval difficulties in logopenic PPA. Additional insight was gained regarding the neural regions that supported improved performance by the administration of a functional magnetic resonance imaging protocol before and after treatment. In the context of a picture-naming task, post-treatment fMRI showed increased activation of left dorsolateral prefrontal regions that have been implicated in functional imaging studies of generative naming in healthy individuals. The increased activation in these frontal regions that were not significantly atrophic in our patient (as determined by voxel-based morphometry) is consistent with the notion that neural plasticity can support compensation for specific language loss, even in the context of progressive neuronal degeneration.
Keyword: Article
URL: http://www.ncbi.nlm.nih.gov/pubmed/21710364
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208072
https://doi.org/10.1007/s12031-011-9579-2
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11
Neural mechanisms of verb argument structure processing in agrammatic aphasic and healthy age-matched listeners
In: Journal of cognitive neuroscience. - Cambridge, Mass. : MIT Press Journals 22 (2010) 9, 1993-2011
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12
Neural plasticity and treatment-induced recovery of sentence processing in agrammatism
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13
Neural plasticity and treatment-induced recovery of sentence processing in agrammatism
In: Faculty Publications (2010)
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14
Neural plasticity and treatment-induced recovery of sentence processing and production in agrammatism
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15
Neural correlates of verb argument structure processing
In: Journal of cognitive neuroscience. - Cambridge, Mass. : MIT Press Journals 19 (2007) 11, 1753-1767
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16
Neural Correlates of Verb Argument Structure Processing
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17
Functional category production in agrammatism: Treatment and generalization effects
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 99 (2006) 1-2, 69-70
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18
Neural Correlates of Verb Argument Structure Processing
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19
Melodic intonation therapy in Persian aphasic patients
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 17 (2003) 1, 75
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20
Melodic intonation therapy in Persian aphasic patients
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 17 (2003) 1, 75-95
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