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1
Face perception enhances insula and motor network reactivity in Tourette syndrome
Abstract: Tourette syndrome is a neurodevelopmental disorder, characterized by motor and phonic tics. Tics are typically experienced as avolitional, compulsive, and associated with premonitory urges. They are exacerbated by stress and can be triggered by external stimuli, including social cues like the actions and facial expressions of others. Importantly, emotional social stimuli, with angry facial stimuli potentially the most potent social threat cue, also trigger behavioural reactions in healthy individuals, suggesting that such mechanisms may be particularly sensitive in people with Tourette syndrome. Twenty-one participants with Tourette syndrome and 21 healthy controls underwent functional MRI while viewing faces wearing either neutral or angry expressions to quantify group differences in neural activity associated with processing social information. Simultaneous video recordings of participants during neuroimaging enabled us to model confounding effects of tics on task-related responses to the processing of faces. In both Tourette syndrome and control participants, face stimuli evoked enhanced activation within canonical face perception regions, including the occipital face area and fusiform face area. However, the Tourette syndrome group showed additional responses within the anterior insula to both neutral and angry faces. Functional connectivity during face viewing was then examined in a series of psychophysiological interactions. In participants with Tourette syndrome, the insula showed functional connectivity with a set of cortical regions previously implicated in tic generation: the presupplementary motor area, premotor cortex, primary motor cortex, and the putamen. Furthermore, insula functional connectivity with the globus pallidus and thalamus varied in proportion to tic severity, while supplementary motor area connectivity varied in proportion to premonitory sensations, with insula connectivity to these regions increasing to a greater extent in patients with worse symptom severity. In addition, the occipital face area showed increased functional connectivity in Tourette syndrome participants with posterior cortical regions, including primary somatosensory cortex, and occipital face area connectivity with primary somatosensory and primary motor cortices varied in proportion to tic severity. There were no significant psychophysiological interactions in controls. These findings highlight a potential mechanism in Tourette syndrome through which heightened representation within insular cortex of embodied affective social information may impact the reactivity of subcortical motor pathways, supporting programmed motor actions that are causally implicated in tic generation. Medicinal and psychological therapies that focus on reducing insular hyper-reactivity to social stimuli may have potential benefit for tic reduction in people with Tourette syndrome.
URL: https://doi.org/10.1093/brain/awy254
http://orca.cf.ac.uk/121483/1/awy254.pdf
http://orca.cf.ac.uk/121483/
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2
Anger in brain and body: the neural and physiological perturbation of decision-making by emotion
Garfinkel, Sarah N.; Zorab, Emma; Navaratnam, Nakulan. - : Oxford University Press, 2016
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3
Anger in brain and body: the neural and physiological perturbation of decision-making by emotion
Garfinkel, Sarah N; Zorab, Emma; Navaratnam, Nakulan. - : Oxford University Press, 2016
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4
Emotional valence and arousal affect reading in an interactive way:neuroimaging evidence for an approach-withdrawal framework
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5
Emotional valence and arousal affect reading in an interactive way: neuroimaging evidence for an approach-withdrawal framework
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6
Emotional valence and arousal affect reading in an interactive way: neuroimaging evidence for an approach-withdrawal framework
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7
Whatever next? Predictive brains, situated agents, and the future of cognitive science : [including open peer commentary and author's response]
In: Behavioral and brain sciences. - New York, NY [u.a.] : Cambridge Univ. Press 36 (2013) 3, 181-253
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8
Extending predictive processing to the body: Emotion as interoceptive inference
In: Behavioral and brain sciences. - New York, NY [u.a.] : Cambridge Univ. Press 36 (2013) 3, 227-228
OLC Linguistik
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9
Abnormalities in fronto-striatal connectivity within language networks relate to differences in grey-matter heterogeneity in Asperger syndrome☆
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10
Abnormalities in fronto-striatal connectivity within language networks relate to differences in grey-matter heterogeneity in Asperger syndrome
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11
Abnormalities in fronto-striatal connectivity within language networks relate to differences in grey-matter heterogeneity in Asperger syndrome
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12
How emotions are shaped by bodily states
Critchley, Hugo D; Nagai, Yoko. - : SAGE Publications, 2012
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13
Interaction between emotional valence and arousal during lexical processing: Neural evidence for an integrated approach-withdrawal framework
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14
Fear recognition ability predicts differences in social cognitive and neural functioning in men
In: Cognitive neuroscience (New York, 2009), 4 ; p. 422-437
MPI für Psycholinguistik
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15
Cognitive functioning after medial frontal lobe damage including the anterior cingulate cortex : a preliminary investigation
In: Brain and cognition. - San Diego, Calif. [u.a.] : Elsevier Science 60 (2006) 2, 166-175
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16
Fear Recognition Ability Predicts Differences in Social Cognitive and Neural Functioning in Men
In: Journal of cognitive neuroscience. - Cambridge, Mass. : MIT Press Journals 18 (2006) 6, 889-897
OLC Linguistik
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17
Imaging informational conflict: a functional magnetic resonance imaging study of numerical Stroop
In: Journal of cognitive neuroscience. - Cambridge, Mass. : MIT Press Journals 18 (2006) 12, 2049-2062
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OLC Linguistik
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18
Anxiety Reduction through Detachment: Subjective, Physiological, and Neural Effects
In: Journal of cognitive neuroscience. - Cambridge, Mass. : MIT Press Journals 17 (2005) 6, 874-883
OLC Linguistik
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19
The functional neuroanatomy of social behaviour : changes in cerebal blood flow when people with autistic disorder process facial expressions
In: Brain. - Oxford : Oxford Univ. Press 123 (2000) 11, 2203-2212
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