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1
Dynamic functional brain network connectivity during pseudoword processing relates to children’s reading skill
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2
Development of a standard of care for patients with valosin-containing protein associated multisystem proteinopathy.
In: Orphanet journal of rare diseases, vol 17, iss 1 (2022)
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3
Family history of FXTAS is associated with age-related cognitive-linguistic decline among mothers with the FMR1 premutation.
In: Journal of neurodevelopmental disorders, vol 14, iss 1 (2022)
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4
Cortical microstructure in primary progressive aphasia: a multicenter study.
In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
Abstract: BackgroundCortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural disorganization and have been proposed as a sensitive biomarker that might antedate macroscopic cortical changes. We aimed to test the hypothesis that cortical mean diffusivity is more sensitive than cortical thickness to detect cortical changes in primary progressive aphasia (PPA).MethodsIn this multicenter, case-control study, we recruited 120 patients with PPA (52 non-fluent, 31 semantic, and 32 logopenic variants; and 5 GRN-related PPA) as well as 89 controls from three centers. The 3-Tesla MRI protocol included structural and diffusion-weighted sequences. Disease severity was assessed with the Clinical Dementia Rating scale. Cortical thickness and cortical mean diffusivity were computed using a surface-based approach.ResultsThe comparison between each PPA variant and controls revealed cortical mean diffusivity increases and cortical thinning in overlapping regions, reflecting the canonical loci of neurodegeneration of each variant. Importantly, cortical mean diffusivity increases also expanded to other PPA-related areas and correlated with disease severity in all PPA groups. Cortical mean diffusivity was also increased in patients with very mild PPA when only minimal cortical thinning was observed and showed a good correlation with measures of disease severity.ConclusionsCortical mean diffusivity shows promise as a sensitive biomarker for the study of the neurodegeneration-related microstructural changes in PPA.
Keyword: 2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Aging; Alzheimer's disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer’s disease; Aphasia; Biomedical Imaging; Brain Disorders; Case-Control Studies; Clinical Research; Dementia; Diffusion; Diffusion Magnetic Resonance Imaging; Frontotemporal Dementia (FTD); Frontotemporal lobar degeneration; Humans; Magnetic resonance; Magnetic Resonance Imaging; Medical and Health Sciences; Neurodegenerative; Neurological; Neurosciences; Primary Progressive; Primary progressive aphasia; Rare Diseases
URL: https://escholarship.org/uc/item/4td346vg
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5
Providing a parent-administered outcome measure in a bilingual family of a father and a mother of two adolescents with ASD: brief report.
In: Developmental neurorehabilitation, vol 25, iss 2 (2022)
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6
Open access dataset of task-free hemodynamic activity in 4-month-old infants during sleep using fNIRS. ...
Blanco, Borja; Molnar, Monika; Carreiras, Manuel. - : Apollo - University of Cambridge Repository, 2022
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7
Entwicklung einer neuronalen Leitstruktur für die biomimetische Freisetzung von Wachstumsfaktoren im Rahmen der cochleären Regeneration ...
Wille, Inga. - : Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2022
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8
A Hermeneutic Phenomenological Study of Teacher Perceptions of the Effects Movement Strategies Have On Student Learning
In: Doctoral Dissertations and Projects (2022)
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9
Anosognosia in Dementia: Evaluation of Perfusion Correlates Using 99mTc-HMPAO SPECT and Automated Brodmann Areas Analysis
In: Diagnostics; Volume 12; Issue 5; Pages: 1136 (2022)
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10
Cerebral Polymorphisms for Lateralisation: Modelling the Genetic and Phenotypic Architectures of Multiple Functional Modules
In: Symmetry; Volume 14; Issue 4; Pages: 814 (2022)
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11
Benefits from Repetitive Transcranial Magnetic Stimulation in Post-Stroke Rehabilitation
In: Journal of Clinical Medicine; Volume 11; Issue 8; Pages: 2149 (2022)
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12
Should Neurosurgeons Try to Preserve Non-Traditional Brain Networks? A Systematic Review of the Neuroscientific Evidence
In: Journal of Personalized Medicine; Volume 12; Issue 4; Pages: 587 (2022)
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13
Emergent Neuroimaging Findings for Written Expression in Children: A Scoping Review
In: Brain Sciences; Volume 12; Issue 3; Pages: 406 (2022)
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14
Advancements in Oncology with Artificial Intelligence—A Review Article
In: Cancers; Volume 14; Issue 5; Pages: 1349 (2022)
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15
Simultaneous Classification of Both Mental Workload and Stress Level Suitable for an Online Passive Brain–Computer Interface
In: Sensors; Volume 22; Issue 2; Pages: 535 (2022)
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16
Expanding the Phenotype of B3GALNT2-Related Disorders
In: Genes; Volume 13; Issue 4; Pages: 694 (2022)
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17
The Neurobiological Correlates of Gaze Perception in Healthy Individuals and Neurologic Patients
In: Biomedicines; Volume 10; Issue 3; Pages: 627 (2022)
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18
Rethinking the Methods and Algorithms for Inner Speech Decoding and Making Them Reproducible
In: NeuroSci; Volume 3; Issue 2; Pages: 226-244 (2022)
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19
CEREBRAL ABSCESS AND MYCOTIC ANEURYSM AS A CONSEQUENCE OF INFECTIVE ENDOCARDITIS: A CASE REPORT ...
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20
CEREBRAL ABSCESS AND MYCOTIC ANEURYSM AS A CONSEQUENCE OF INFECTIVE ENDOCARDITIS: A CASE REPORT ...
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