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1
Protocol for SonoSpeech Cleft Pilot: a mixed-methods pilot randomized control trial of ultrasound visual biofeedback versus standard intervention for children with cleft lip and palate
In: Pilot Feasibility Stud (2022)
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2
The ASCEND study: protocol for a feasibility study to evaluate an early social communication intervention for young children with Down syndrome
In: Pilot Feasibility Stud (2022)
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3
The MultimorbiditY COllaborative Medication Review And DEcision Making (MyComrade) study: a protocol for a cross-border pilot cluster randomised controlled trial
In: Pilot Feasibility Stud (2022)
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4
Parental Report via a Mobile App in the Context of Early Language Trajectories: StarWords Study Protocol
In: Int J Environ Res Public Health (2022)
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5
The Efficacy of Lingual Laser Frenectomy in Pediatric OSAS: A Randomized Double-Blinded and Controlled Clinical Study
In: Int J Environ Res Public Health (2021)
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6
Protocol for the development of a core outcome set for lateral elbow tendinopathy (COS-LET)
In: Trials (2021)
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7
Protocol for Escitalopram and Language Intervention for Subacute Aphasia (ELISA): A randomized, double blind, placebo-controlled trial
In: PLoS One (2021)
Abstract: In this forthcoming multicenter, prospective, randomized, double-blind placebo-controlled trial, we will investigate the augmentative effects of a selective serotonin reuptake inhibitor, escitalopram, on language therapy in individuals with post-stroke aphasia. We hypothesize that, when combined with language therapy, daily escitalopram will result in greater improvement than placebo in an untrained picture naming task (Philadelphia Naming Test short form) administered one week after the end of language therapy. We also will examine whether escitalopram’s effect on language is independent of its effect on depression, varies with lesion location, or is associated with increased functional connectivity within the left hemisphere. Finally, we will examine whether individuals with BDNF met alleles show reduced response to treatment and reduced changes in connectivity. We expect to enroll 88 participants over four years. Participants are given escitalopram or placebo within one week of their stroke for 90 days and receive fifteen 45-minute computer-delivered sessions of language treatment beginning 60 days from the start of drug therapy. Patients then complete a comprehensive assessment of language at one, five, and twenty weeks after the last language therapy session. ELISA is the first randomized, controlled trial evaluating the effect of a selective serotonin reuptake inhibitor on the improvement of language in people with aphasia undergoing language treatment during the acute to subacute post-stroke period. Trial registration: The trial is registered with ClinicalTrials.gov NCT03843463.
Keyword: Study Protocol
URL: https://doi.org/10.1371/journal.pone.0261474
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699636/
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8
Augmentative and alternative communication intervention for in-patient individuals with post-stroke aphasia: study protocol of a parallel-group, pragmatic randomized controlled trial
In: Trials (2021)
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9
Evaluation of the efficacy of hearing aids in older adults: a multiparametric longitudinal study protocol
In: BMC Geriatr (2021)
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10
Video decision support tool promoting values conversations in advanced care planning in cancer: protocol of a randomised controlled trial
In: BMC Palliat Care (2021)
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11
A culturally adapted brief intervention for post-traumatic stress disorder in people with severe mental illness in Botswana: protocol for a randomised feasibility trial
In: Pilot Feasibility Stud (2021)
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12
Feasibility study protocol of a pragmatic, randomised controlled pilot trial: membrane sweeping to prevent post-term pregnancy—the MILO Study
In: Trials (2021)
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13
Reflective practice across speech and language therapy and education: a protocol for an integrative review
In: HRB Open Res (2021)
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14
A mixed method study design to explore the adherence of haematological cancer patients to oral anticancer medication in a multilingual and multicultural outpatient setting: The MADESIO protocol
In: PLoS One (2021)
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15
Japanese health and safety information for overseas visitors: protocol for a randomized controlled trial
In: BMC Public Health (2021)
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16
Effects of Early Vocal Contact in the Neonatal Intensive Care Unit: Study Protocol for a Multi-Centre, Randomised Clinical Trial
In: Int J Environ Res Public Health (2021)
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17
Knowledge and attitudes of schoolteachers in the Pacific Islands to childhood hearing loss and hearing services: A national survey protocol for Samoa
In: SAGE Open Med (2021)
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18
Neural correlates of treatment effect and prediction of treatment outcome in patients with PTSD and comorbid personality disorder: study design
In: Borderline Personal Disord Emot Dysregul (2021)
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19
Emotional Regulation in Teens and Improvement of Constructive Skills (EmoTIConS): study protocol for a randomized controlled trial
In: Trials (2021)
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20
Effects of foreign language learning on executive functions in healthy older adults: study protocol for a randomised controlled trial
In: BMC Geriatr (2021)
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