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Cortical microstructure in primary progressive aphasia: a multicenter study.
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Illán-Gala, Ignacio; Montal, Victor; Borrego-Écija, Sergi; Mandelli, Maria Luisa; Falgàs, Neus; Welch, Ariane E; Pegueroles, Jordi; Santos-Santos, Miguel; Bejanin, Alexandre; Alcolea, Daniel; Dols-Icardo, Oriol; Belbin, Olivia; Sánchez-Saudinós, Mª Belén; Bargalló, Nuria; González-Ortiz, Sofía; Lladó, Albert; Blesa, Rafael; Dickerson, Bradford C; Rosen, Howard J; Miller, Bruce L; Lleó, Alberto; Gorno-Tempini, Maria Luisa; Sánchez-Valle, Raquel; Fortea, Juan
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In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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Abstract:
BackgroundCortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural disorganization and have been proposed as a sensitive biomarker that might antedate macroscopic cortical changes. We aimed to test the hypothesis that cortical mean diffusivity is more sensitive than cortical thickness to detect cortical changes in primary progressive aphasia (PPA).MethodsIn this multicenter, case-control study, we recruited 120 patients with PPA (52 non-fluent, 31 semantic, and 32 logopenic variants; and 5 GRN-related PPA) as well as 89 controls from three centers. The 3-Tesla MRI protocol included structural and diffusion-weighted sequences. Disease severity was assessed with the Clinical Dementia Rating scale. Cortical thickness and cortical mean diffusivity were computed using a surface-based approach.ResultsThe comparison between each PPA variant and controls revealed cortical mean diffusivity increases and cortical thinning in overlapping regions, reflecting the canonical loci of neurodegeneration of each variant. Importantly, cortical mean diffusivity increases also expanded to other PPA-related areas and correlated with disease severity in all PPA groups. Cortical mean diffusivity was also increased in patients with very mild PPA when only minimal cortical thinning was observed and showed a good correlation with measures of disease severity.ConclusionsCortical mean diffusivity shows promise as a sensitive biomarker for the study of the neurodegeneration-related microstructural changes in PPA.
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Keyword:
2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Aging; Alzheimer's disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer’s disease; Aphasia; Biomedical Imaging; Brain Disorders; Case-Control Studies; Clinical Research; Dementia; Diffusion; Diffusion Magnetic Resonance Imaging; Frontotemporal Dementia (FTD); Frontotemporal lobar degeneration; Humans; Magnetic resonance; Magnetic Resonance Imaging; Medical and Health Sciences; Neurodegenerative; Neurological; Neurosciences; Primary Progressive; Primary progressive aphasia; Rare Diseases
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URL: https://escholarship.org/uc/item/4td346vg
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| 2 |
Analysis of ancestry heterozygosity suggests that hybrid incompatibilities in threespine stickleback are environment dependent.
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In: PLoS biology, vol 20, iss 1 (2022)
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| 3 |
Ecclesiastical Pressures and Language Politics: The Boundary Work of Albanian Language in the 17th-18th Centuries
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In: ISSN: 0090-5992 ; EISSN: 1465-3923 ; Nationalities Papers ; https://halshs.archives-ouvertes.fr/halshs-03648536 ; Nationalities Papers, Taylor & Francis (Routledge), 2022, pp.1-28. ⟨10.1017/nps.2021.55⟩ (2022)
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| 4 |
Edinburgh Postnatal Depression Scale (EPDS) for screening for depression in the first year post delivery in a low-resourced rural setting in Kenya ...
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Edinburgh Postnatal Depression Scale (EPDS) for screening for depression in the first year post delivery in a low-resourced rural setting in Kenya ...
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| 6 |
Dialectic as Ostension Towards the Transcendent: Language and Mystical Intersubjectivity in Plotinus’ Enneads ...
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'Tis but Thy Name: Semantic Question Answering Evaluation with 11M Names for 1M Entities ...
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| 10 |
MLLP-VRAIN Spanish ASR Systems for the Albayzín-RTVE 2020 Speech-to-Text Challenge: Extension
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In: Applied Sciences; Volume 12; Issue 2; Pages: 804 (2022)
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| 11 |
Emotional and Social Engagement in the English Language Classroom for Higher Education Students in the COVID-19 Online Context
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In: Sustainability; Volume 14; Issue 8; Pages: 4527 (2022)
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| 12 |
Behavior Problems and Social Competence in Fragile X Syndrome: A Systematic Review
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In: Genes; Volume 13; Issue 2; Pages: 280 (2022)
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| 15 |
The Roles of the ADOS-2 and Cognition in Measuring and Diagnosing Autism Spectrum Disorder
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In: Psychology Dissertations (2022)
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| 18 |
Neural Natural Language Generation: A Survey on Multilinguality, Multimodality, Controllability and Learning
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| 19 |
Behavior Problems and Social Competence in Fragile X Syndrome: A Systematic Review
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In: Genes (Basel) (2022)
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| 20 |
The Structure of Social Networks and Its Link to Higher Education Students’ Socio-Emotional Loneliness During COVID-19
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In: Front Psychol (2022)
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