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Investigating the Mechanisms Driving Referent Selection and Retention in Toddlers at Typical and Elevated Likelihood for Autism Spectrum Disorder. ...
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Investigating the Mechanisms Driving Referent Selection and Retention in Toddlers at Typical and Elevated Likelihood for Autism Spectrum Disorder.
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Neural and behavioural indices of face processing in siblings of children with autism spectrum disorder (ASD): a longitudinal study from infancy to mid-childhood
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Gaze following and attention to objects in infants at familial risk for ASD
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Gaze Following and Attention to Objects in Infants at Familial Risk for ASD.
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Gaze Following and Attention to Objects in Infants at Familial Risk for ASD
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Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years. ...
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Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years.
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Randomised trial of a parent-mediated intervention for infants at high risk for autism: Longitudinal outcomes to age 3 years
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Green, Jonathan; Pickles, Andrew; Pasco, Greg; Bedford, Rachael; Wan, Ming Wai; Elsabbagh, Mayada; Slonims, Vicky; Jones, Emily; Cheung, Celeste; Charman, Tony; Johnson, Mark; British Autism Study of Infant Siblings (BASIS) Team. - 2017
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Abstract:
BACKGROUND: There has been increasing interest in the potential for pre-emptive interventions in the prodrome of autism, but little investigation as to their effect. METHODS: A two-site, two-arm assessor-blinded randomised controlled trial (RCT) of a 12-session parent-mediated social communication intervention delivered between 9 and 14 months of age (Intervention in the British Autism Study of Infant Siblings-Video Interaction for Promoting Positive Parenting), against no intervention. Fifty-four infants (28 intervention, 26 nonintervention) at familial risk of autism but not otherwise selected for developmental atypicality were assessed at 9-month baseline, 15-month treatment endpoint, and 27- and 39-month follow-up. PRIMARY OUTCOME: severity of autism prodromal symptoms, blind-rated on Autism Observation Schedule for Infants or Autism Diagnostic Observation Schedule 2nd Edition across the four assessment points. SECONDARY OUTCOMES: blind-rated parent-child interaction and child language; nonblind parent-rated communication and socialisation. Prespecified intention-to-treat analysis combined estimates from repeated measures within correlated regressions to estimate the overall effect of the infancy intervention over time. RESULTS: Effect estimates in favour of intervention on autism prodromal symptoms, maximal at 27 months, had confidence intervals (CIs) at each separate time point including the null, but showed a significant overall effect over the course of the intervention and follow-up period (effect size [ES] = 0.32; 95% CI 0.04, 0.60; p = .026). Effects on proximal intervention targets of parent nondirectiveness/synchrony (ES = 0.33; CI 0.04, 0.63; p = .013) and child attentiveness/communication initiation (ES = 0.36; 95% CI 0.04, 0.68; p = .015) showed similar results. There was no effect on categorical diagnostic outcome or formal language measures. CONCLUSIONS: Follow-up to 3 years of the first RCT of a very early social communication intervention for infants at familial risk of developing autism has shown a treatment effect, extending 24 months after intervention end, to reduce the overall severity of autism prodromal symptoms and enhance parent-child dyadic social communication over this period. We highlight the value of extended follow-up and repeat assessment for early intervention trials.
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URL: https://ueaeprints.uea.ac.uk/id/eprint/75581/ https://doi.org/10.1111/jcpp.12728 https://ueaeprints.uea.ac.uk/id/eprint/75581/1/Published_Version.pdf
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Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years
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Enhanced visual search in infancy predicts emerging autism symptoms
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Enhanced Visual Search in Infancy Predicts Emerging Autism Symptoms
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Early gross motor skills predict the subsequent development of language in children with autism spectrum disorder
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Predicting the rate of language development from early motor skills in at-risk infants who develop autism spectrum disorder
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Failure to learn from feedback underlies word learning difficulties in toddlers at risk for autism.
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In: Journal of Child Language, 40(1): 29-46 (2013)
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Failure to learn from feedback underlies word learning difficulties in toddlers at risk for autism
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