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Improving Shared Decision Making in Latino Men With Prostate Cancer: A Thematic Analysis.
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In: MDM policy & practice, vol 6, iss 1 (2021)
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Improving Shared Decision Making in Latino Men With Prostate Cancer: A Thematic Analysis.
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In: MDM policy & practice, vol 6, iss 1 (2021)
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Improving Shared Decision Making in Latino Men With Prostate Cancer: A Thematic Analysis ...
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Improving Shared Decision Making in Latino Men With Prostate Cancer: A Thematic Analysis ...
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Epidemiology of Traumatic Brain Injury in Europe: A Living Systematic Review
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In: J Neurotrauma (2021)
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Communication Challenges Faced by Spanish-Speaking Caregivers of Children with Medical Complexity: a Qualitative Study
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In: J Racial Ethn Health Disparities (2021)
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Improving Shared Decision Making in Latino Men With Prostate Cancer: A Thematic Analysis
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In: MDM Policy Pract (2021)
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Combining Microbial Culturing With Mathematical Modeling in an Introductory Course-Based Undergraduate Research Experience.
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Combining Microbial Culturing With Mathematical Modeling in an Introductory Course-Based Undergraduate Research Experience.
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Individual differences in learning the regularities between orthography, phonology and semantics predict early reading skills
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In: J Mem Lang (2020)
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The Visual Array Task: A Novel Gaze-Based Measure of Object Label and Category Knowledge
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In: Dev Sci (2020)
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Combining Microbial Culturing With Mathematical Modeling in an Introductory Course-Based Undergraduate Research Experience
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In: Front Microbiol (2020)
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Differential Activation of the Visual Word Form Area During Auditory Phoneme Perception in Youth with Dyslexia
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In: Neuropsychologia (2020)
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Mapping typical and hypokinetic dysarthric speech production network using a connected speech paradigm in functional MRI
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In: Neuroimage Clin (2020)
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Abstract:
We developed a task paradigm whereby subjects spoke aloud while minimizing head motion during functional MRI (fMRI) in order to better understand the neural circuitry involved in motor speech disorders due to dysfunction of the central nervous system. To validate our overt continuous speech paradigm, we mapped the speech production network (SPN) in typical speakers (n = 19, 10 females) and speakers with hypokinetic dysarthria as a manifestation of Parkinson disease (HKD; n = 21, 8 females) in fMRI. We then compared it with the SPN derived during overt speech production by (15)O-water PET in the same group of typical speakers and another HKD cohort (n = 10, 2 females). The fMRI overt connected speech paradigm did not result in excessive motion artifacts and successfully identified the same brain areas demonstrated in the PET studies in the two cohorts. The SPN derived in fMRI demonstrated significant spatial overlap with the corresponding PET derived maps (typical speakers: r = 0.52; speakers with HKD: r = 0.43) and identified the components of the neural circuit of speech production belonging to the feedforward and feedback subsystems. The fMRI study in speakers with HKD identified significantly decreased activity in critical feedforward (bilateral dorsal premotor and motor cortices) and feedback (auditory and somatosensory areas) subsystems replicating previous PET study findings in this cohort. These results demonstrate that the overt connected speech paradigm is feasible during fMRI and can accurately localize the neural substrates of typical and disordered speech production. Our fMRI paradigm should prove useful for study of motor speech and voice disorders, including stuttering, apraxia of speech, dysarthria, and spasmodic dysphonia.
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Keyword:
Regular Article
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URL: https://doi.org/10.1016/j.nicl.2020.102285 http://www.ncbi.nlm.nih.gov/pubmed/32521476 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284131/
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Communication disorders in young children with cerebral palsy
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Conjunctive Constraints and Templates in Optimality Theory
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In: North East Linguistics Society (2020)
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Directional Footing, Degeneracy, and Alignment
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In: North East Linguistics Society (2020)
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Restaurant Inspection and Training Factors Associated with Foodborne Disease and Food Handler Knowledge
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Spanish Validation of the PICCOLO (Parenting Interactions With Children: Checklist of Observations Linked to Outcomes)
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Spanish Validation of the PICCOLO (Parenting Interactions With Children: Checklist of Observations Linked to Outcomes)
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In: Institute for Disability Research, Policy & Practice Publications (2019)
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