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GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.
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In: Molecular psychiatry, vol 22, iss 3 (2017)
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Gwas meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the cogent consortium
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GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
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Examining non-syndromic autosomal recessive intellectual disability (NS-ARID) genes for an enriched association with intelligence differences
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GWAS-based pathway analysis differentiates between fluid and crystallized intelligence
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Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins
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Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins
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Genetic copy number variation and general cognitive ability.
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In: PLoS One , 7 (12) , Article e37385 . (2012) (2012)
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Genome-wide association studies establish that human intelligence is highly heritable and polygenic
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In: MOL PSYCHIATR , 16 (10) 996 - 1005. (2011) (2011)
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Genome-wide association studies establish that human intelligence is highly heritable and polygenic
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Davies, G.; Tenesa, A.; Payton, A.; Yang, J.; Harris, S. E.; Liewald, D.; Ke, X.; Le Hellard, S.; Christoforou, A.; Luciano, M.; McGhee, K.; Lopez, L.; Gow, A. J.; Corley, J.; Redmond, P.; Fox, H. C.; Haggarty, P.; Whalley, L. J.; McNeill, G.; Goddard, M. E.; Espeseth, T.; Lundervold, A. J.; Reinvang, I.; Pickles, A.; Steen, V. M.; Ollier, W.; Porteous, D. J.; Horan, M.; Starr, J. M.; Pendleton, N.; Visscher, P. M.. - : Nature Publishing Group, 2011
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Abstract:
General intelligence is an important human quantitative trait that accounts for much of the variation in diverse cognitive abilities. Individual differences in intelligence are strongly associated with many important life outcomes, including educational and occupational attainments, income, health and lifespan. Data from twin and family studies are consistent with a high heritability of intelligence, but this inference has been controversial. We conducted a genome-wide analysis of 3511 unrelated adults with data on 549 692 single nucleotide polymorphisms (SNPs) and detailed phenotypes on cognitive traits. We estimate that 40% of the variation in crystallized-type intelligence and 51% of the variation in fluid-type intelligence between individuals is accounted for by linkage disequilibrium between genotyped common SNP markers and unknown causal variants. These estimates provide lower bounds for the narrow-sense heritability of the traits. We partitioned genetic variation on individual chromosomes and found that, on average, longer chromosomes explain more variation. Finally, using just SNP data we predicted similar to 1% of the variance of crystallized and fluid cognitive phenotypes in an independent sample (P=0.009 and 0.028, respectively). Our results unequivocally confirm that a substantial proportion of individual differences in human intelligence is due to genetic variation, and are consistent with many genes of small effects underlying the additive genetic influences on intelligence. Molecular Psychiatry (2011) 16, 996-1005; doi:10.1038/mp.2011.85; published online 9 August 2011
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Keyword:
1312 Molecular Biology; 2738 Psychiatry and Mental health; 2804 Cellular and Molecular Neuroscience; Genetics; Genome wide association study; Intelligence; Quantitative trait
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URL: https://espace.library.uq.edu.au/view/UQ:307744
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Cathepsin D exon 2 polymorphism associated with general intelligence in a healthy older population.
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