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Functional Connectivity and Speech Entrainment Speech Entrainment Improves Connectivity Between Anterior and Posterior Cortical Speech Areas in Non-fluent Aphasia ...
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Functional Connectivity and Speech Entrainment Speech Entrainment Improves Connectivity Between Anterior and Posterior Cortical Speech Areas in Non-fluent Aphasia ...
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Speech Entrainment Improves Connectivity Between Anterior and Posterior Cortical Speech Areas in Non-Fluent Aphasia
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In: Neurorehabil Neural Repair (2022)
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Abstract:
BACKGROUND: Speech entrainment (SE), the online mimicking of an audiovisual speech model, has been shown to increase speech fluency in individuals with non-fluent aphasia. One theory that may explain why SE improves speech output is that it synchronizes functional connectivity between anterior and posterior language regions to be more similar to that of neurotypical speakers. OBJECTIVES: The present study tested this by measuring functional connectivity between two regions shown to be necessary for speech production, and their right hemisphere homologues, in 24 persons with aphasia compared to 20 controls during both free (spontaneous) speech and SE. METHODS: Functional connectivity values in each person with aphasia were normalized to the control data. Two analyses were carried out: 1) functional connectivity values were compared between persons with aphasia and controls during free speech and SE and 2) stepwise linear models with leave-one-out cross validation including normed functional connectivity during both tasks and proportion damage to the left hemisphere as independent variables were created for each language score. RESULTS: Left hemisphere anterior-posterior functional connectivity and left hemisphere posterior to right hemisphere anterior functional connectivity were significantly more similar to connectivity of the control group during SE compared to free speech. Additionally, connectivity during free speech was more strongly associated with language measures than connectivity during SE. CONCLUSIONS: Overall, these results suggest that SE promotes normalization of functional connectivity (i.e., return to patterns observed in neurotypical controls), which may explain why individuals with aphasia produce more fluent speech during SE compared to spontaneous speech.
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982955/ https://doi.org/10.1177/15459683211064264 http://www.ncbi.nlm.nih.gov/pubmed/34968159
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Isolating the white matter circuitry of the dorsal language stream: Connectome‐Symptom Mapping in stroke induced aphasia
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In: Hum Brain Mapp (2021)
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Independent contributions of structural and functional connectivity: Evidence from a stroke model
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In: Netw Neurosci (2021)
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2018 ASHA Research Symposium: Julius Fridricksson, BDNF Genotype & Brain Activation in Aphasia ...
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2018 ASHA Research Symposium: Julius Fridricksson, BDNF Genotype & Brain Activation in Aphasia ...
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Machine learning‐based multimodal prediction of language outcomes in chronic aphasia
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In: Hum Brain Mapp (2020)
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2018 ASHA Research Symposium: Julius Fridricksson, BDNF Genotype & Brain Activation in Aphasia ...
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BDNF genotype & brain activation in aphasia (Kristinsson et al., 2019) ...
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BDNF genotype & brain activation in aphasia (Kristinsson et al., 2019) ...
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Progression of Aphasia Severity in the Chronic Stages of Stroke
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Leukoaraiosis is associated with a decline in language abilities in chronic aphasia
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In: Neurorehabil Neural Repair (2019)
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Cortical and structural-connectivity damage correlated with impaired syntactic processing in aphasia
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Brain-Derived Neurotrophic Factor Genotype–Specific Differences in Cortical Activation in Chronic Aphasia
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