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Functional Connectivity and Speech Entrainment Speech Entrainment Improves Connectivity Between Anterior and Posterior Cortical Speech Areas in Non-fluent Aphasia ...
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Functional Connectivity and Speech Entrainment Speech Entrainment Improves Connectivity Between Anterior and Posterior Cortical Speech Areas in Non-fluent Aphasia ...
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Speech Entrainment Improves Connectivity Between Anterior and Posterior Cortical Speech Areas in Non-Fluent Aphasia
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In: Neurorehabil Neural Repair (2022)
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Isolating the white matter circuitry of the dorsal language stream: Connectome‐Symptom Mapping in stroke induced aphasia
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In: Hum Brain Mapp (2021)
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Independent contributions of structural and functional connectivity: Evidence from a stroke model
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In: Netw Neurosci (2021)
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2018 ASHA Research Symposium: Julius Fridricksson, BDNF Genotype & Brain Activation in Aphasia ...
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2018 ASHA Research Symposium: Julius Fridricksson, BDNF Genotype & Brain Activation in Aphasia ...
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Machine learning‐based multimodal prediction of language outcomes in chronic aphasia
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In: Hum Brain Mapp (2020)
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2018 ASHA Research Symposium: Julius Fridricksson, BDNF Genotype & Brain Activation in Aphasia ...
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BDNF genotype & brain activation in aphasia (Kristinsson et al., 2019) ...
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BDNF genotype & brain activation in aphasia (Kristinsson et al., 2019) ...
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Progression of Aphasia Severity in the Chronic Stages of Stroke
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Leukoaraiosis is associated with a decline in language abilities in chronic aphasia
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In: Neurorehabil Neural Repair (2019)
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Abstract:
BACKGROUND: A fraction of stroke survivors with chronic aphasia experience declines in language abilities over time, but the reason for this remains unclear. OBJECTIVE: To evaluate the effect of leukoaraiosis on baseline aphasia severity and long-term changes in aphasia severity. This study directly compares the predictive capacity of leukoaraiosis severity to that of lesion damage, a factor known to account for a substantial proportion of variance in the degree of language impairment and recovery. METHODS: Using a longitudinal database of behavioral and neuroimaging data from 35 individuals in the chronic stage of recovery after a single-event left-hemisphere stroke (9 females, mean stroke age=55.8±9.1 years, mean months post-stroke at initial evaluation=36.3±40.8), we examined two lines of inquiry: 1) to what extent does leukoaraiosis severity at initial evaluation predict aphasia severity and 2) to what extent does leukoaraiosis severity at initial evaluation predict longitudinal change in aphasia severity. Participants underwent high-resolution MRI for the purpose of lesion volume analysis and leukoaraiosis severity rating. Biographical information was also considered. RESULTS: Lesion volume and time post-stroke at initial assessment best predicted initial aphasia severity (adjusted R(2)=0.37). Leukoaraiosis severity and initial aphasia severity significantly predicted decline in language abilities at follow-up, accounting for approximately one-third of the variance (adjusted R(2)=0.33). More severe leukoaraiosis was associated with a 4.3 odds increase of decline. CONCLUSIONS: Leukoaraiosis is a significant risk factor for declining language abilities in aphasia and should be considered for better identification of individuals at risk for long-term decline, which can guide clinical decision making.
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URL: https://doi.org/10.1177/1545968319862561 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693961/ http://www.ncbi.nlm.nih.gov/pubmed/31315507
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Cortical and structural-connectivity damage correlated with impaired syntactic processing in aphasia
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Brain-Derived Neurotrophic Factor Genotype–Specific Differences in Cortical Activation in Chronic Aphasia
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