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Pediatric traumatic brain injury: language outcomes and their relationship to the arcuate fasciculus.
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In: Brain Lang , 127 (3) 388 - 398. (2013) (2013)
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| 2 |
Pediatric traumatic brain injury: Language outcomes and their relationship to the arcuate fasciculus
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In: Brain and Language , 127 (3) 388 - 398. (2013) (2013)
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Abstract:
Pediatric traumatic brain injury (TBI) may result in long-lasting language impairments alongside dysarthria, a motor-speech disorder. Whether this co-morbidity is due to the functional links between speech and language networks, or to widespread damage affecting both motor and language tracts, remains unknown.Here we investigated language function and diffusion metrics (using diffusion-weighted tractography) within the arcuate fasciculus, the uncinate fasciculus, and the corpus callosum in 32 young people after TBI (approximately half with dysarthria) and age-matched healthy controls (. n=. 17). Only participants with dysarthria showed impairments in language, affecting sentence formulation and semantic association. In the whole TBI group, sentence formulation was best predicted by combined corpus callosum and left arcuate volumes, suggesting this "dual blow" seriously reduces the potential for functional reorganisation. Word comprehension was predicted by fractional anisotropy in the right arcuate. The co-morbidity between dysarthria and language deficits therefore seems to be the consequence of multiple tract damage. © 2013 Elsevier Inc.
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URL: http://discovery.ucl.ac.uk/1418658/
http://discovery.ucl.ac.uk/1418658/1/1-s2.0-S0093934X13001016-main.pdf
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| 3 |
Endophenotypes of FOXP2: Dysfunction within the human articulatory network
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In: EUR J PAEDIATR NEURO , 15 (4) 283 - 288. (2011) (2011)
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Speaking with a single cerebral hemisphere: fMRI language organization after hemispherectomy in childhood
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In: BRAIN LANG , 106 (3) 195 - 203. (2008) (2008)
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| 5 |
Cortical abnormalities and language function in young patients with basal ganglia stroke
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In: NEUROIMAGE , 36 (2) 431 - 440. (2007) (2007)
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Language reorganization in children with early-onset lesions of the left hemisphere: an fMRI study
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In: BRAIN , 127 1229 - 1236. (2004) (2004)
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| 7 |
Cortical lateralization during verb generation: a combined ERP and fMRI study
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In: NEUROIMAGE , 22 (2) 665 - 675. (2004) (2004)
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| 8 |
Functional MRI abnormalities during covert speech associated with FOXP2 gene mutation
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In: Nature Neuroscience , 6 (11 ) pp.1230 - 1237 . (2003) (2003)
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| 9 |
Language fMRI abnormalities associated with FOXP2 gene mutation
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In: NAT NEUROSCI , 6 (11) 1230 - 1237. (2003) (2003)
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| 10 |
Cortical representation of language studied with event related potentials (ERPS) and functional magnetic resonance imaging (fMRI)
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In: J COGNITIVE NEUROSCI 89 - 89. (2002) (2002)
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| 11 |
Cortical representation of language studied with event related potentials (ERPS) and functional magnetic resonance imaging (fMRI)
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In: Presented at: UNSPECIFIED. (2002) (2002)
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| 12 |
MRI analysis of an inherited speech and language disorder: structural brain abnormalities.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2002)
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