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Polygenic Scores for Cognitive Abilities and Their Association with Different Aspects of General Intelligence—A Deep Phenotyping Approach
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Genç, Erhan; Schlüter, Caroline; Fraenz, Christoph; Arning, Larissa; Metzen, Dorothea; Nguyen, Huu Phuc; Voelkle, Manuel C.; Streit, Fabian; Güntürkün, Onur; Kumsta, Robert; Ocklenburg, Sebastian
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In: Mol Neurobiol (2021)
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Abstract:
Intelligence is a highly polygenic trait and genome-wide association studies (GWAS) have identified thousands of DNA variants contributing with small effects. Polygenic scores (PGS) can aggregate those effects for trait prediction in independent samples. As large-scale light-phenotyping GWAS operationalized intelligence as performance in rather superficial tests, the question arises which intelligence facets are actually captured. We used deep-phenotyping to investigate the molecular determinants of individual differences in cognitive ability. We, therefore, studied the association between PGS of intelligence (IQ-PGS), cognitive performance (CP-PGS), and educational attainment (EA-PGS) with a wide range of intelligence facets in a sample of 557 healthy adults. IQ-PGS, CP-PGS, and EA-PGS had the highest incremental R(2)s for general (2.71%; 4.27%; 2.06%), verbal (3.30%; 4.64%; 1.61%), and numerical intelligence (3.06%; 3.24%; 1.26%) and the weakest for non-verbal intelligence (0.89%; 1.47%; 0.70%) and memory (0.80%; 1.06%; 0.67%). These results indicate that PGS derived from light-phenotyping GWAS do not reflect different facets of intelligence equally well, and thus should not be interpreted as genetic indicators of intelligence per se. The findings refine our understanding of how PGS are related to other traits or life outcomes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12035-021-02398-7.
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Keyword:
Article
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280022/
https://doi.org/10.1007/s12035-021-02398-7
http://www.ncbi.nlm.nih.gov/pubmed/33954905
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A large-scale estimate on the relationship between language and motor lateralization
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A large-scale estimate on the relationship between language and motor lateralization
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In: Sci Rep (2020)
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Humans recognize emotional arousal in vocalizations across all classes of terrestrial vertebrates: evidence for acoustic universals
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In: ISSN: 0962-8452 ; EISSN: 1471-2954 ; Proceedings of the Royal Society B: Biological Sciences ; https://hal.archives-ouvertes.fr/hal-03434314 ; Proceedings of the Royal Society B: Biological Sciences, Royal Society, The, 2017, 284 (1859), pp.20170990. ⟨10.1098/rspb.2017.0990⟩ (2017)
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Learning Morse Code Alters Microstructural Properties in the Inferior Longitudinal Fasciculus: A DTI Study
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Ein neues Verfahren zur Untersuchung der auditiven und Sprach-Verarbeitung von Kindern ab 4 Jahren: eine psychoakustische und MMN-Studie ...
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