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Primary Progressive Aphasia Associated With GRN Mutations: New Insights Into the Non-amyloid Logopenic Variant
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In: ISSN: 0028-3878 ; EISSN: 1526-632X ; Neurology ; https://hal.archives-ouvertes.fr/hal-03281660 ; Neurology, American Academy of Neurology, 2021, ⟨10.1212/wnl.0000000000012174⟩ (2021)
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Language Network Connectivity Increases in Early Alzheimer’s Disease
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In: J Alzheimers Dis (2021)
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Abstract:
BACKGROUND: Language production deficits occur early in the course of Alzheimer’s disease (AD); however, only a few studies have focused on language network’s functional connectivity in mild cognitive impairment (MCI) due to AD. OBJECTIVE: The current study aims to uncover the extent of language alteration at the MCI stage, at a behavioral and neural level, using univariate and multivariate analyses of structural MRI and resting-state fMRI. METHODS: Twenty-four MCI due to AD participants and 24 matched healthy controls underwent a comprehensive language evaluation, a structural T1-3D MRI, and resting-state fMRI. We performed seed-based analyses, using the left inferior frontal gyrus and left posterior temporal gyrus as seeds. Then, we analyzed connectivity between executive control networks and language network in each group. Finally, we used multivariate pattern analyses to test whether the two groups could be distinguished based on the pattern of atrophy within the language network; within the executive control networks, as well as the pattern of functional connectivity within the language network and within the executive control networks. RESULTS: MCI due to AD participants had language impairment during standardized language tasks and connected-speech production. Regarding functional connectivity, univariate analyses were not able to discriminate participants, while multivariate pattern analyses could significantly predict participants’ group. Language network’s functional connectivity could discriminate MCI due to AD participants better than executive control networks. Most notably, they revealed an increased connectivity at the MCI stage, positively correlated with language performance. CONCLUSION: Multivariate analyses represent a useful tool for investigating the functional and structural (re-)organization of the neural bases of language.
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Keyword:
Research Article
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293644/ http://www.ncbi.nlm.nih.gov/pubmed/34024825 https://doi.org/10.3233/JAD-201584
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Structural, Microstructural, and Metabolic Alterations in Primary Progressive Aphasia Variants
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In: ISSN: 1664-2295 ; Frontiers in Neurology ; https://hal.inria.fr/hal-01897015 ; Frontiers in Neurology, Frontiers, 2018, 9, ⟨10.3389/fneur.2018.00766⟩ (2018)
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Structural, microstructural and metabolic alterations in Primary Progressive Aphasia variants
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In: Annual meeting of the Organization for Human Brain Mapping - OHBM 2018 ; https://hal.inria.fr/hal-01764289 ; Annual meeting of the Organization for Human Brain Mapping - OHBM 2018, Jun 2018, Singapore, Singapore (2018)
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Inter-individual variability in discourse informativeness in elderly populations
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Structural, Microstructural, and Metabolic Alterations in Primary Progressive Aphasia Variants
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Inter-individual variability in discourse informativeness in elderly populations ...
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Inter-individual variability in discourse informativeness in elderly populations ...
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Pauses During Autobiographical Discourse Reflect Episodic Memory Processes in Early Alzheimer’s Disease
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