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1
A Virtual, Randomized, Control Trial of a Digital Therapeutic for Speech, Language, and Cognitive Intervention in Post-stroke Persons With Aphasia ; Frontiers in Neurology
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2
An Efficient Bedside Measure Yields Prognostic Implications for Language Recovery in Acute Stroke Patients
In: Cogn Behav Neurol (2020)
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3
Stealing Cookies in the Twenty-First Century: Measures of Spoken Narrative in Healthy Versus Speakers With Aphasia
Berube, Shauna; Nonnemacher, Jodi; Demsky, Cornelia. - : American Speech-Language-Hearing Association, 2019
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4
Leukoaraiosis is independently associated with naming outcome in poststroke aphasia
Wright, Amy; Tippett, Donna; Saxena, Sadhvi. - : Lippincott Williams & Wilkins, 2018
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5
Predicting Recovery in Acute Post-stroke Aphasia
Abstract: OBJECTIVE: Many stroke patients show remarkable recovery of language after initial severe impairment, but it is difficult to predict which patients will show good recovery. We aimed to identify patient and lesion characteristics that together predict the best naming outcome in four studies. METHODS: We report two longitudinal studies that identified two variables at onset that were strongly associated with good recovery of naming (the most common residual deficit in aphasia) in the first six months after stroke: damage to left posterior superior temporal gyrus (pSTG) and/or superior longitudinal fasciculus/arcuate fasciculus (SLF/AF) and selective serotonin reuptake inhibitor (SSRI) use. We then tested these variables in two independent cohorts of chronic left hemisphere stroke patients, using chi squared tests and multivariable logistic regression for dichotomous outcomes and t-tests for continuous outcomes. RESULTS: Lesion load in left pSTG and SLF/AF was associated with poorer naming outcome. Preservation of these areas and use of SSRIs were associated with naming recovery, independent of lesion volume, time since stroke, and depression. Patients with damage to these critical areas showed better naming outcome if they took SSRIs for three months after stroke. Those with preservation of these critical areas achieved good recovery of naming regardless of SSRI use. INTERPRETATION: Lesion load in left pSTG and SLF/AF at onset predicts later naming performance. Although based on a small number of patients, our preliminary results suggest outcome might be modulated by SSRIs, but these associations need to be confirmed in a larger randomized controlled trial.
Keyword: Article
URL: https://doi.org/10.1002/ana.25184
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867273/
http://www.ncbi.nlm.nih.gov/pubmed/29451321
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6
Cerebellar tDCS: A Novel Approach to Augment Language Treatment Post-stroke
Sebastian, Rajani; Saxena, Sadhvi; Tsapkini, Kyrana. - : Frontiers Media S.A., 2017
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