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The Contribution of Working Memory Areas to Verbal Learning and Recall in Primary Progressive Aphasia
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In: Front Neurol (2022)
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Sonorant spectra and coarticulation distinguish speakers with different dialects ...
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| 3 |
Effects of tDCS on Sound Duration in Patients with Apraxia of Speech in Primary Progressive Aphasia
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In: Brain Sci (2021)
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A Systematic Review of Transcranial Direct Current Stimulation in Primary Progressive Aphasia: Methodological Considerations
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In: Front Aging Neurosci (2021)
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Selective Functional Network Changes Following tDCS-Augmented Language Treatment in Primary Progressive Aphasia
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In: Front Aging Neurosci (2021)
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Abstract:
OBJECTIVE: Transcranial direct current stimulation (tDCS) has shown promising results when used as an adjunct to behavioral training in neurodegenerative diseases. However, the underlying neural mechanisms are not understood and neuroimaging evidence from pre/post treatment has been sparse. In this study, we examined tDCS-induced neural changes in a language intervention study for primary progressive aphasia (PPA), a neurodegenerative syndrome with language impairment as the primary clinical presentation. Anodal tDCS was applied to the left inferior frontal gyrus (LIFG). To evaluate the hypothesis that tDCS promotes system segregation, analysis focused on understanding tDCS-induced changes in the brain-wide functional network connectivity of the targeted LIFG. METHODS: Resting-state fMRI data were obtained from 32 participants with PPA before and after receiving a written naming therapy, accompanied either by tDCS or sham stimulation. We focused on evaluating changes in the global connectivity of the stimulated LIFG-triangularis (LIFG-tri) region given its important role in lexical processing. Global connectivity was indexed by the graph-theoretic measure participation coefficient (PC) which quantifies a region’s level of system segregation. The values before and after treatment were compared for each condition (tDCS or Sham) as well as with age-matched healthy controls (n = 19). RESULTS: Higher global connectivity of the LIFG-tri before treatment was associated with greater dementia severity. After treatment, the tDCS group showed a significant decrease in global connectivity whereas the Sham group’s did not change, suggesting specific neural effects induced by tDCS. Further examination revealed that the decrease was driven by reduced connectivity between the LIFG-tri and regions outside the perisylvian language area, consistent with the hypothesis that tDCS enhances the segregation of the language system and improves processing efficiency. Additionally, we found that these effects were specific to the LIFG-tri and not observed in other control regions. CONCLUSION: TDCS-augmented language therapy in PPA increased the functional segregation of the language system, a normalization of the hyper-connectivity observed before treatment. These findings add to our understanding of the nature of tDCS-induced neural changes in disease treatment and have applications for validating treatment efficacy and designing future tDCS and other non-invasive brain stimulation (NIBS) treatments.
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Keyword:
Neuroscience
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URL: http://www.ncbi.nlm.nih.gov/pubmed/34322010
https://doi.org/10.3389/fnagi.2021.681043
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311858/
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| 6 |
Part of Speech Production in Patients With Primary Progressive Aphasia: An Analysis Based on Natural Language Processing
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In: Am J Speech Lang Pathol (2021)
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A Tool for Automatic Scoring of Spelling Performance
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In: J Speech Lang Hear Res (2020)
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| 8 |
White Matter Hyperintensities Contribute to Language Deficits in Primary Progressive Aphasia
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In: Cogn Behav Neurol (2020)
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Different patterns of functional network re-organization across the variants of primary progressive aphasia: A graph theoretic analysis
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In: Neurobiol Aging (2020)
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| 10 |
Effects of executive attention on sentence processing in aphasia
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In: Aphasiology (2019)
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| 11 |
The use of spelling for variant classification in primary progressive aphasia: Theoretical and practical implications
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In: Neuropsychologia (2019)
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| 12 |
The Role of Word Properties in Performance on Fluency Tasks in People with Primary Progressive Aphasia
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| 13 |
“The effect of tDCS on functional connectivity in primary progressive aphasia” NeuroImage: Clinical, volume 19 (2018), pages 703–715
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| 14 |
Written Verb Naming Improves After tDCS Over the Left IFG in Primary Progressive Aphasia
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| 15 |
The Role of Language Severity and Education in Explaining Performance on Object and Action Naming in Primary Progressive Aphasia
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Cerebellar tDCS: A Novel Approach to Augment Language Treatment Post-stroke
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Transcranial Direct Current Stimulation in Post Stroke Aphasia and Primary Progressive Aphasia: Current Knowledge and Future Clinical Applications
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