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Thalamic but Not Subthalamic Neuromodulation Simplifies Word Use in Spontaneous Language
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Abstract:
Several investigations have shown language impairments following electrode implantation surgery for Deep Brain Stimulation (DBS) in movement disorders. The impact of the actual stimulation, however, differs between DBS targets with further deterioration in formal language tests induced by thalamic DBS in contrast to subtle improvement observed in subthalamic DBS. Here, we studied speech samples from interviews with participants treated with DBS of the thalamic ventral intermediate nucleus (VIM) for essential tremor (ET), or the subthalamic nucleus (STN) for Parkinson’s disease (PD), and healthy volunteers (each n = 13). We analyzed word frequency and the use of open and closed class words. Active DBS increased word frequency in case of VIM, but not STN stimulation. Further, relative to controls, both DBS groups produced fewer open class words. Whereas VIM DBS further decreased the proportion of open class words, it was increased by STN DBS. Thus, VIM DBS favors the use of relatively common words in spontaneous language, compatible with the idea of lexical simplification under thalamic stimulation. The absence or even partial reversal of these effects in patients receiving STN DBS is of interest with respect to biolinguistic concepts suggesting dichotomous thalamic vs. basal ganglia roles in language processing. ; Peer Reviewed
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Keyword:
610 Medizin und Gesundheit; ddc:610; deep brain stimulation; frequency effect; language; lexical access; lexical frequency; spontaneous language; thalamus
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URN:
urn:nbn:de:kobv:11-110-18452/23833-6
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URL: http://edoc.hu-berlin.de/18452/23833
https://doi.org/10.3389/fnhum.2021.656188
https://doi.org/10.18452/23218
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| 64 |
SPECIFIC FEATURES OF APPLICATION OF SPECIAL KNOWLEDGE IN ASSESSMENT OF LEXIC CONSTRUCTIONS CONTAINING DISCUSSED (OBSCENE) VOCABULARY (IN RUSSIAN) ...
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| 67 |
Introducing Linked Open Data Living Informational Books ...
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| 68 |
Introducing Linked Open Data Living Informational Books ...
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| 69 |
Challenges of Word Sense Alignment: Portuguese Language Resources ...
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| 70 |
A good TACTIC for lexicographical work: football terms encoded in TEI Lex-0 ...
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| 71 |
Modelling Etymology in LMF/TEI: The 'Grande Dicionário Houaiss da Língua Portuguesa' Dictionary as a Use Case. ...
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| 72 |
Encoding polylexical units with TEI Lex-o: A case study ...
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| 73 |
Open Legal Data: Freie juristische Daten im Rechtsstaat ...
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| 74 |
Comprender el mundo para mejorar un diccionario: las marcas temáticas en el Diccionario de la lengua española de la Real Academia Española ...
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| 75 |
A good TACTIC for lexicographical work: football terms encoded in TEI Lex-0 ...
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| 76 |
Challenges of Word Sense Alignment: Portuguese Language Resources ...
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| 77 |
O projeto Edição Digital dos Vocabulários da Academia das Ciências:o VOLP-1940 ...
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| 78 |
O projeto Edição Digital dos Vocabulários da Academia das Ciências:o VOLP-1940 ...
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| 79 |
Comprender el mundo para mejorar un diccionario: las marcas temáticas en el Diccionario de la lengua española de la Real Academia Española ...
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| 80 |
Encoding polylexical units with TEI Lex-o: A case study ...
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