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Lifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia. ...
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Sala, Arianna; Malpetti, Maura; Farsad, Mohsen; Lubian, Francesca; Magnani, Giuseppe; Frasca Polara, Giulia; Epiney, Jean-Benoit; Abutalebi, Jubin; Assal, Frédéric; Garibotto, Valentina; Perani, Daniela. - : Apollo - University of Cambridge Repository, 2022
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Abstract:
Lifelong bilingualism is associated with delayed dementia onset, suggesting a protective effect on the brain. Here, we aim to study the effects of lifelong bilingualism as a dichotomous and continuous phenomenon, on brain metabolism and connectivity in individuals with Alzheimer's dementia. Ninety-eight patients with Alzheimer's dementia (56 monolinguals; 42 bilinguals) from three centers entered the study. All underwent an [18F]-fluorodeoxyglucose positron emission tomography (PET) imaging session. A language background questionnaire measured the level of language use for conversation and reading. Severity of brain hypometabolism and strength of connectivity of the major neurocognitive networks was compared across monolingual and bilingual individuals, and tested against the frequency of second language life-long usage. Age, years of education, and MMSE score were included in all above mentioned analyses as nuisance covariates. Cerebral hypometabolism was more severe in bilingual compared to monolingual ...
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Keyword:
Alzheimer disease; default mode network; fluorodeoxyglucose F18; multilingualism; positron‐emission tomography; RESEARCH ARTICLE; RESEARCH ARTICLES
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URL: https://dx.doi.org/10.17863/cam.77664 https://www.repository.cam.ac.uk/handle/1810/330222
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Bilingualism and Aging: Implications for (Delaying) Neurocognitive Decline
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In: Front Hum Neurosci (2022)
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Lifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia.
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First Language Attrition: What It Is, What It Isn’t, and What It Can Be
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In: Front Hum Neurosci (2021)
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First Language Attrition: What It Is, What It Isn’t, and What It Can Be
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Cognitive and brain reserve in bilinguals: field overview and explanatory mechanisms
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The role of the cognitive control system in recovery from bilingual aphasia: a multiple single-case fMRI study
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Second language performances in elderly bilinguals and individuals with dementia: The role of L2 immersion
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Language Control and Lexical Competition in Bilinguals: An Event-Related fMRI Study
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How bilingualism protects the brain from aging: insights from bimodal bilinguals
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The impact of bilingualism on brain reserve and metabolic connectivity in Alzheimer's dementia
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Semantic interference and its control: A functional neuroimaging and connectivity study
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In: ISSN: 1065-9471 ; EISSN: 1097-0193 ; Human Brain Mapping ; https://hal.archives-ouvertes.fr/hal-01452813 ; Human Brain Mapping, Wiley, 2016, 37 (11), pp.4179-4196. ⟨10.1002/hbm.23304⟩ (2016)
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The Role of the Cognitive Control System in Recovery from Bilingual Aphasia: A Multiple Single-Case fMRI Study
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A diffusion model approach to analysing the bilingual advantage for the Flanker task: the role of attentional control processes
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