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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 18 of 18 1 Lifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia. ... Sala, Arianna; Malpetti, Maura; Farsad, Mohsen. - : Apollo - University of Cambridge Repository, 2022 BASE Show details 2 Lifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia. Sala, Arianna; Malpetti, Maura; Farsad, Mohsen; Lubian, Francesca; Magnani, Giuseppe; Frasca Polara, Giulia; Epiney, Jean-Benoit; Abutalebi, Jubin; Assal, Frédéric; Garibotto, Valentina; Perani, Daniela. - : Wiley, 2021. : Hum Brain Mapp, 2021 Abstract: Lifelong bilingualism is associated with delayed dementia onset, suggesting a protective effect on the brain. Here, we aim to study the effects of lifelong bilingualism as a dichotomous and continuous phenomenon, on brain metabolism and connectivity in individuals with Alzheimer's dementia. Ninety-eight patients with Alzheimer's dementia (56 monolinguals; 42 bilinguals) from three centers entered the study. All underwent an [18F]-fluorodeoxyglucose positron emission tomography (PET) imaging session. A language background questionnaire measured the level of language use for conversation and reading. Severity of brain hypometabolism and strength of connectivity of the major neurocognitive networks was compared across monolingual and bilingual individuals, and tested against the frequency of second language life-long usage. Age, years of education, and MMSE score were included in all above mentioned analyses as nuisance covariates. Cerebral hypometabolism was more severe in bilingual compared to monolingual patients; severity of hypometabolism positively correlated with the degree of second language use. The metabolic connectivity analyses showed increased connectivity in the executive, language, and anterior default mode networks in bilingual compared to monolingual patients. The change in neuronal connectivity was stronger in subjects with higher second language use. All effects were most pronounced in the left cerebral hemisphere. The neuroprotective effects of lifelong bilingualism act both against neurodegenerative processes and through the modulation of brain networks connectivity. These findings highlight the relevance of lifelong bilingualism in brain reserve and compensation, supporting bilingual education and social interventions aimed at usage, and maintenance of two or more languages, including dialects, especially crucial in the elderly people. Keyword: Alzheimer disease; default mode network; fluorodeoxyglucose F18; multilingualism; positron‐emission tomography; RESEARCH ARTICLE; RESEARCH ARTICLES URL: https://doi.org/10.17863/CAM.77664 https://www.repository.cam.ac.uk/handle/1810/330222 BASE Hide details 3 Speech production differences in English and Italian speakers with nonfluent variant PPA Canu, Elisa; Agosta, Federica; Battistella, Giovanni... In: Neurology (2020) BASE Show details 4 The clinico-metabolic correlates of language impairment in corticobasal syndrome and progressive supranuclear palsy Dodich, Alessandra; Cerami, Chiara; Inguscio, Emanuela... In: ISSN: 2213-1582 ; NeuroImage: Clinical (2019) P. 102009 (2019) BASE Show details 5 Northwestern Anagram Test-Italian (Nat-I) for primary progressive aphasia Canu, Elisa; Agosta, Federica; Imperiale, Francesca... In: Cortex (2019) BASE Show details 6 Prevalence of amyloid‐β pathology in distinct variants of primary progressive aphasia Bergeron, David; Gorno-Tempini, Maria; Rabinovici, Gil... In: ISSN: 0364-5134 ; EISSN: 1531-8249 ; Annals of Neurology ; https://hal-univ-fcomte.archives-ouvertes.fr/hal-03630161 ; Annals of Neurology, Wiley, 2018, 84 (5), pp.729-740. ⟨10.1002/ana.25333⟩ (2018) BASE Show details 7 Prevalence of amyloid‐β pathology in distinct variants of primary progressive aphasia Bergeron, David; Gorno-Tempini, Maria,; Rabinovici, Gil,... In: ISSN: 0364-5134 ; EISSN: 1531-8249 ; Annals of Neurology ; https://www.hal.inserm.fr/inserm-02749861 ; Annals of Neurology, Wiley, 2018, 84 (5), pp.729-740. ⟨10.1002/ana.25333⟩ (2018) BASE Show details 8 Prevalence of Amyloid-β Pathology in Distinct Variants of Primary Progressive Aphasia Bergeron, David; Gorno-Tempini, Maria L.; Rabinovici, Gil D.. - 2018 BASE Show details 9 Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia: Amyloid-β Pathology in PPA Bergeron, David; Gorno-Tempini, Maria L.; Rabinovici, Gil D.... In: Annals of Neurology. - 84, 5 (2018) , 729-740, ISSN: 0364-5134 (2018) BASE Show details 10 The impact of bilingualism on brain reserve and metabolic connectivity in Alzheimer's dementia Perani, Daniela; Farsad, Mohsen; Ballarini, Tommaso. - : National Academy of Sciences, 2017 BASE Show details 11 The Role of Single-Subject Brain Metabolic Patterns in the Early Differential Diagnosis of Primary Progressive Aphasias and in Prediction of Progression to Dementia Cerami, Chiara; Dodich, Alessandra; Greco, Lucia. - : IOS Press, 2016 BASE Show details 12 A multimodal neuroimaging study of a case of crossed nonfluent/agrammatic primary progressive aphasia Spinelli, Edoardo G.; Caso, Francesca; Agosta, Federica. - 2015 BASE Show details 13 The Semantic Variant of Primary Progressive Aphasia: Clinical and Neuroimaging Evidence in Single Subjects Iaccarino, Leonardo; Crespi, Chiara; Della Rosa, Pasquale Anthony. - : Public Library of Science, 2015 BASE Show details 14 In vivo signatures of nonfluent/agrammatic primary progressive aphasia caused by FTLD pathology Caso, Francesca; Mandelli, Maria Luisa; Henry, Maya. - 2014 BASE Show details 15 In vivo signatures of nonfluent/agrammatic primary progressive aphasia caused by FTLD pathology Caso, Francesca; Mandelli, Maria Luisa; Henry, Maya. - : Lippincott Williams & Wilkins, 2014 BASE Show details 16 Disruption of structural connectivity along the dorsal and ventral language pathways in patients with nonfluent and semantic variant primary progressive aphasia: A DT MRI study and a literature review Agosta, Federica; Galantucci, Sebastiano; Canu, Elisa... In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 127 (2013) 2, 157-166 OLC Linguistik Show details 17 Nonfluent/agrammatic PPA with in-vivo cortical amyloidosis and Pick's disease pathology. Caso, Francesca; Gesierich, Benno; Henry, Maya... In: Behavioural neurology, vol 26, iss 1-2 (2013) BASE Show details 18 Nonfluent/agrammatic PPA with in-vivo cortical amyloidosis and Pick’s disease pathology Caso, Francesca; Gesierich, Benno; Henry, Maya. - 2013 BASE Show details

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