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Bilingualism's Effects on Resting-State Functional Connectivity in Mild Cognitive Impairment
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A cross-sectional and longitudinal study on the protective effect of bilingualism against dementia using brain atrophy and cognitive measures
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Costumero, Víctor; Marin Marin, Lidon; Calabria, Marco; Belloch, Vicente; Escudero, Joaquín; Baquero, Miguel; Hernández Pardo, Mireia; Ruiz de Miras, Juan; Costa Martínez, Albert, 1970-; Parcet, Maria Antònia; Ávila, César. - : BioMed Central, 2020
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Abstract:
Background: Evidence from previous studies suggests that bilingualism contributes to cognitive reserve because bilinguals manifest the first symptoms of Alzheimer's disease (AD) up to 5 years later than monolinguals. Other cross-sectional studies demonstrate that bilinguals show greater amounts of brain atrophy and hypometabolism than monolinguals, despite sharing the same diagnosis and suffering from the same symptoms. However, these studies may be biased by possible pre-existing between-group differences. Methods: In this study, we used global parenchymal measures of atrophy and cognitive tests to investigate the protective effect of bilingualism against dementia cross-sectionally and prospectively, using a sample of bilinguals and monolinguals in the same clinical stage and matched on sociodemographic variables. Results: Our results suggest that the two groups did not differ in their cognitive status at baseline, but bilinguals had less parenchymal volume than monolinguals, especially in areas related to brain atrophy in dementia. In addition, a longitudinal prospective analysis revealed that monolinguals lost more parenchyma and had more cognitive decline than bilinguals in a mean follow-up period of 7 months. Conclusion: These results provide the first prospective evidence that bilingualism may act as a neuroprotective factor against dementia and could be considered a factor in cognitive reserve.
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Keyword:
Alzheimer's disease; Bilingualism; Bilingüisme; Malaltia d'Alzheimer
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URL: http://hdl.handle.net/2445/163857
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| 3 |
A cross-sectional and longitudinal study on the protective effect of bilingualism against dementia using brain atrophy and cognitive measures
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BASE
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Show details
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| 4 |
A cross-sectional and longitudinal study on the protective effect of bilingualism against dementia using brain atrophy and cognitive measures.
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BASE
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| 5 |
Effects of bilingualism on white matter atrophy in mild cognitive impairment: a diffusion tensor imaging study
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Efectos neuroprotectores del bilingüismo contra la demencia. Un estudio de morfometría basada en el voxel
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| 7 |
A Cross-sectional and longitudinal study on the protective effect of bilingualism against dementia using brain atrophy and cognitive measures
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BASE
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Show details
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