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Hits 1 – 3 of 3
1
The Trans-Ancestral Genomic Architecture of Glycemic Traits
Chen, Ji
;
Spracklen, Cassandra N.
;
Marenne, Gaëlle
...
In: Nat Genet (2021)
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2
Novel genetic loci associated with hippocampal volume
Hibar, Derrek P.
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Adams, Hieab H. H.
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Jahanshad, Neda
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Chauhan, Ganesh
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Stein, Jason L.
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Hofer, Edith
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Renteria, Miguel E.
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Bis, Joshua C.
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Arias-Vasquez, Alejandro
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Ikram, M. Kamran
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Desrivières, Sylvane
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Vernooij, Meike W.
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Abramovic, Lucija
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Alhusaini, Saud
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Amin, Najaf
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Andersson, Micael
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Arfanakis, Konstantinos
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Aribisala, Benjamin S.
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Armstrong, Nicola J.
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Athanasiu, Lavinia
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Axelsson, Tomas
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Beecham, Ashley H.
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Beiser, Alex
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Bernard, Manon
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Blanton, Susan H.
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Bohlken, Marc
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Boks, Marco
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Bralten, Janita
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Brickman, Adam m.
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Carmichael, Owen
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Chakravarty, M. Mallar
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Chen, Qiang
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Ching, Christopher
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Chouraki, Vincent
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Cuellar-Partida, Gabriel
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Crivello, Fabrice
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den Braber, Anouk
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Doan, Nhat Trung
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Ehrlich, Stefan
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Giddaluru, Sudheer
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Goldman, Aaron L.
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Gottesman, Rebecca F.
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Grimm, Oliver
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Griswold, Michael E.
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Guadalupe, Tulio
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Gutman, Boris A.
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Hass, Johanna
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Haukvik, Unn K.
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Hoehn, David
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Ho, Avram J.
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Hoogman, Martine
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Janowitz, Deborah
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Jia, Tianye
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Jørgensen, Kjetil N.
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Karbalai, Nazanin
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Kasperaviciute, Dalia
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Kim, Sungeun
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Klein, Marieke
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Kraemer, Bernd
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Lee, Phil H.
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Liewald, David C.
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Lopez, Lorna M.
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Luciano, Michelle
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Macare, Christine
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Marquand, André F.
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Matarin, Mar
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Mather, Karen A.
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Mattheisen, Manuel
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McKay, David
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Milaneschi, Yuri
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Muñoz Maniega, Susana
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Nho, Kwangsik
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Nugent, Allison C.
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Nyquist, Paul
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Loohuis, Loes M. Olde
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Oosterlaan, Jaap
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Papmeyer, Martina
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Pirpamer, Lukas
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Pütz, Benno
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Ramasamy, Adaikalavan
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Richards, Jennifer S.
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Risacher, Shannon L.
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Roiz-Santiañez, Robert
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Rommelse, Nanda
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Ropele, Stefan
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Rose, Emma
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Royle, Natalie A.
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Rundek, Tatjana
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Sämann, Philipp G.
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Saremi, Arvin
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Satizabal, Claudia L.
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Schmaal, Lianne
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Schork, Andrew
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Shen, Li
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Shin, Jean
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Shumskaya, Elena
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Smith, Albert
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Sprooten, Emma
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Strike, Lachlan T.
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Teumer, Alexander
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Tordesillas-Gutierrez, Diana
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Toro, Roberto
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Trabzuni, Daniah
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Trompet, Stella
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Vaidya, Dhananjay
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van der Grond, Jeroen
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Van der Lee, Sven
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Van der Meer, Dennis
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Van Donkelaar, Marjolein M. J.
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Van Eijk, Kristel R.
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Van Erp, Theo G. M.
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Van Rooij, Daan
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Walton, Esther
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Westlye, Lars
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Whelan, Christophe
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Windham, Beverly G.
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Winkler, Anderson M.
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Wittfeld, Katharina
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Woldehawariat, Girma
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Wolf, Christiane
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Wolfers, Thomas
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Yanek, Lisa R.
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Yang, Jingyun
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Zijdenbos, Alex
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Zwiers, Marcel
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Agartz, Ingrid
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Almasy, Laura
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Ames, David
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Amouyel, Philippe
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Andreassen, Ole A
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Arepalli, Sampath
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Assareh, Amelia A.
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Barral, Sandra
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Bastin, Mark
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Becker, Diane M.
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Becker, James T.
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Bennett, David A.
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Blangero, John
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Van Bokhoven, Hans
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Boomsma, Dorret I.
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Brodaty, Henry
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Brouwer, Rachel M.
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Brunner, Han G.
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Buckner, Randy L.
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Buitelaar, Jan K.
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Bulayeva, Kazima B.
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Cahn, Wiepke
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Calhoun, Vince D.
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Cannon, Dara M.
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Cavalleri, Gianpiero L.
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Cheng, Ching-Yu
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Cichon, Sven
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Cookson, Mark
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Corvin, Aiden
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Crespo-Facorro, Benedicto
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Curran, Joanne E.
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Czisch, Michael
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Dale, Anders M.
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Davies, Gareth E.
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de Craen, Anton J. M.
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de Geus, Eco J. C.
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De Jager, Philip L.
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De Zubicaray, Greig I.
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Deary, Ian
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Debette, Stéphanie
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DeCarli, Charles
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Delanty, Norman
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Depondt, Chantal
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DeStefano, Anita
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Dillman, Allissa
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Djurovic, Srdjan
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Donohoe, Gary
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Drevets, Wayne C.
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Duggirala, Ravi
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Dyer, Thomas
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Enzinger, Christian
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Erk, Susanne
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Espeseth, Thomas
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Fedko, Iryna O.
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Fernández, Guillén
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Ferrucci, Luigi
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Fisher, Simon
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Fleischman, Debra A.
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Ford, Ian
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Fornage, Myriam
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Foroud, Tatiana M.
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Fox, Peter
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Francks, Clyde
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Fukunaga, Masaki
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Gibbs, J. Raphael
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Glahn, David C.
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Gollub, Randy L.
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Göring, Harald H. H.
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Green, Robert
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Gruber, Oliver
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Gudnason, Vilmundur
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Guelfi, Sebastian
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Håberg, Asta K.
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Hansell, Narelle K.
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Hardy, John
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Hartman, Catharina A.
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Hashimoto, Ryota
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Hegenscheid, Katrin
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Heinz, Andreas
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Le Hellard, Stephanie
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Hernandez, Dena G.
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Heslenfeld, Dirk J.
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Ho, Beng-Choon
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Hoekstra, Pieter J.
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Hoffmann, Wolfgang
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Hofman, Albert
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Holsboer, Florian
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Homuth, Georg
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Hosten, Norbert
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Hottenga, Jouke-Jan
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Huentelman, Matthew
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Pol, Hilleke E. Hulshoff
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Ikeda, Masashi
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Jack Jr, Clifford R.
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Jenkinson, Mark
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Johnson, Robert
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Jönsson, Erik G.
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Jukema, J. Wouter
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Kahn, René S.
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Kanai, Ryota
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Kloszewska, Iwona
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Knopman, David S.
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Kochunov, Peter
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Kwok, John B.
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Lawrie, Stephen M.
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Lemaître, Hervé
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Liu, Xinmin
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Longo, Dan L.
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Lopez, Oscar L.
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Lovestone, Simon
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Martinez, Oliver
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Martinot, Jean-Luc
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Mattay, Venkata S.
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McDonald, Colm
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Mcintosh, Andrew
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McMahon, Francis J.
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Mcmahon, Katie L.
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Mecocci, Patrizia
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Melle, Ingrid
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Meyer-Lindenberg, Andreas
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Mohnke, Sebastian
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Montgomery, Grant W.
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Morris, Derek W.
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Mosley, Thomas H.
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Mühleisen, Thomas W.
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Müller-Myhsok, Bertram
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Nalls, Michael A.
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Nauck, Matthias
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Nichols, Thomas E.
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Niessen, Wiro J.
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Nöthen, Markus M.
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Nyberg, Lars
;
Ohi, Kazutaka
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Olvera, Rene L.
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Ophoff, Roel A.
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Pandolfo, Massimo
;
Paus, Tomas
;
Pausova, Zdenka
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Penninx, Brenda W. J. H.
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Pike, G. Bruce
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Potkin, Steven G.
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Psaty, Bruce M.
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Reppermund, Simone
;
Rietschel, Marcella
;
Roffman, Joshua L.
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Romanczuk-Seiferth, Nina
;
Rotter, Jerome I.
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Ryten, Mina
;
Sacco, Ralph L.
;
Sachdev, Perminder S.
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Saykin, Andrew
;
Schmidt, Reinhold
;
Schmidt, Helena
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Schofield, Peter R.
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Sigursson, Sigurdur
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Simmons, Andrew
;
Singleton, Andrew
;
Sisodiya, Sanjay M.
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Smith, Colin
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Smoller, Jordan W.
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Soininen, Hilkka
;
Steen, Vidar M.
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Stott, David J.
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Sussmann, Jessika E.
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Thalamuthu, Anbupalam
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Toga, Arthur W.
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Traynor, Bryan J.
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Troncoso, Juan
;
Tsolaki, Magda
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Tzourio, Christophe
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Uitterlinden, Andre G.
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Hernández, Maria C. Valdés
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van der Brug, Marcel
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van der Lugt, Aad
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van der Wee, Nic J. A.
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Van Haren, Neeltje E. M.
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van ’t Ent, Dennis
;
van Tol, Marie-Jose
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Vardarajan, Badri N.
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Vellas, Bruno
;
Veltman, Dick J.
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Völzke, Henry
;
Walter, Henrik
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Wardlaw, Joanna M.
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Wassink, Thomas H.
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Weale, Michael E.
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Weinberger, Daneil R
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Weiner, Michael W.
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Wen, Wei
;
Westman, Eric
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White, Tonya
;
Wong, Tien Y.
;
Wright, Clinton B.
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Zielke, Ronald H.
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Zonderman, Alan B.
;
Martin, Nicholas G.
;
Van Duijn, Cornelia M.
;
Wright, Margaret J.
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Longstreth, W. T.
;
Schumann, Gunter
;
Grabe, Hans J.
;
Franke, Barbara
;
Launer, Lenore J.
;
Medland, Sarah E.
;
Seshadri, Sudha
;
Thompson, Paul M.
;
Ikram, M. Arfan
In: ISSN: 2041-1723 ; EISSN: 2041-1723 ; Nature Communications ; https://hal.archives-ouvertes.fr/hal-01488337 ; Nature Communications, Nature Publishing Group, 2017, 8, pp.13624. ⟨10.1038/ncomms13624⟩ (2017)
Abstract:
International audience ; The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r g ¼ À 0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
Keyword:
[SCCO.NEUR]Cognitive science/Neuroscience
URL:
https://hal.archives-ouvertes.fr/hal-01488337/file/ncomms13624.pdf
https://doi.org/10.1038/ncomms13624
https://hal.archives-ouvertes.fr/hal-01488337
https://hal.archives-ouvertes.fr/hal-01488337/document
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3
Novel genetic loci underlying human intracranial volume identified through genome-wide association
Adams, Hieab H H
;
Hibar, Derrek P
;
Chouraki, Vincent
...
In: ISSN: 1097-6256 ; EISSN: 1546-1726 ; Nature Neuroscience ; https://hal.archives-ouvertes.fr/hal-01382716 ; Nature Neuroscience, Nature Publishing Group, 2016, 19 (12), pp.1569-1582. ⟨10.1038/nn.4398⟩ (2016)
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