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Hippocampal ensembles represent sequential relationships among an extended sequence of nonspatial events.
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In: Nature communications, vol 13, iss 1 (2022)
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Balancing Prediction and Sensory Input in Speech Comprehension: The Spatiotemporal Dynamics of Word Recognition in Context. ...
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Balancing Prediction and Sensory Input in Speech Comprehension: The Spatiotemporal Dynamics of Word Recognition in Context.
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Developmental social communication deficits in the Shank3 rat model of phelan-mcdermid syndrome and autism spectrum disorder.
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In: Autism research : official journal of the International Society for Autism Research, vol 11, iss 4 (2018)
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Thin-film micro-electrode stimulation of the cochlea in rats exposed to aminoglycoside induced hearing loss
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In: Australian Institute for Innovative Materials - Papers (2016)
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Parole d'introduzione
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In: Zeitschrift für romanische Philologie, vol. 132, no. 4 (2016)
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Estudo da carcinogênese bucal experimental utilizando-se o óxido de nitroquinolina (4-NQO) em ratos
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Ação do curcumin sobre os períodos iniciais da carcinogênese bucal induzida por 4-NQO em modelo murino
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A mouse model of otitis media identifies HB-EGF as a mediator of inflammation-induced mucosal proliferation.
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In: PloS one, vol 9, iss 7 (2014)
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Apc-Mutant Kyoto Apc Delta (KAD) Rats Are Susceptible to 4-NQO-Induced Tongue Carcinogenesis
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In: Cancers ; Volume 6 ; Issue 3 ; Pages 1522-1539 (2014)
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| 12 |
Un fals aparegut en el «Tirant lo Blanch»
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In: Caplletra. Revista Internacional de Filologia; Núm. 44 (2008); 55-78 (2014)
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Similarity of cortical activity patterns predicts generalization behavior.
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In: PloS one, vol 8, iss 10 (2013)
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| 14 |
Интонация как средство формальной дифференциации лексико-семантических вариантов многозначного слова в русском языке
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Москвичева, Светлана. - : Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования «Российский университет дружбы народов», 2011
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| 15 |
AGILE: Autonomous Global Integrated Language Exploitation
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In: DTIC (2009)
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| 16 |
Conceptual representations in goal-directed decision making.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2008)
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| 18 |
Neuropharmacological modulation of cognitive deficits after brain damage
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In: CURR OPIN NEUROL , 18 (6) 675 - 680. (2005) (2005)
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| 19 |
Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa-induced dyskinesias.
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In: The European journal of neuroscience, vol 18, iss 6 (2003)
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Abstract:
The majority of Parkinson's disease patients undergoing levodopa therapy develop disabling motor complications (dyskinesias) within 10 years of treatment. Stimulation of cannabinoid receptors, the pharmacological target of Delta 9-tetrahydrocannabinol, is emerging as a promising therapy to alleviate levodopa-associated dyskinesias. However, the mechanisms underlying this beneficial action remain elusive, as do the effects exerted by levodopa therapy on the endocannabinoid system. Although levodopa is known to cause changes in CB1 receptor expression in animal models of Parkinson's disease, we have no information on whether this drug alters the brain concentrations of the endocannabinoids anandamide and 2-arachidonylglycerol. To address this question, we used an isotope dilution assay to measure endocannabinoid levels in the caudate-putamen, globus pallidus and substantia nigra of intact and unilaterally 6-OHDA-lesioned rats undergoing acute or chronic treatment with levodopa (50 mg/kg). In intact animals, systemic administration of levodopa increased anandamide concentrations throughout the basal ganglia via activation of dopamine D1/D2 receptors. In 6-OHDA-lesioned rats, anandamide levels were significantly reduced in the caudate-putamen ipsilateral to the lesion; however, neither acute nor chronic levodopa treatment affected endocannabinoid levels in these animals. In lesioned rats, chronic levodopa produced increasingly severe oro-lingual involuntary movements which were attenuated by the cannabinoid agonist R(+)-WIN55,212-2 (1 mg/kg). This effect was reversed by the CB1 receptor antagonist rimonabant (SR141716A). These results indicate that a deficiency in endocannabinoid transmission may contribute to levodopa-induced dyskinesias and that these complications may be alleviated by activation of CB1 receptors.
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Keyword:
2-arachidonylglycerol; 6-hydroxydopamine; anandamide; Animal; Animals; Antiparkinson Agents; Basal Ganglia; Behavior; Benzazepines; Benzoxazines; Brain Chemistry; Cannabinoid; Cannabinoid Receptor Modulators; CB1; Chromatography; Cognitive Sciences; Disease Models; Dopamine Antagonists; Drug Interactions; Drug-Induced; Dyskinesia; Dyskinesias; Endocannabinoids; fatty acid ethanolamides; Gas Chromatography-Mass Spectrometry; High Pressure Liquid; Levodopa; Male; Morpholines; Mouth; Naphthalenes; Neurology & Neurosurgery; Neurosciences; Oxidopamine; Parkinson Disease; Piperidines; Psychology; Pyrazoles; Raclopride; Rats; Receptor; Rimonabant; Substantia Nigra; Time Factors; Wistar
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URL: https://escholarship.org/uc/item/9jz0q6hw
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| 20 |
Speech perception in rats: Use of duration and rise time cues in labeling of affricate/fricative sounds
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In: J EXP ANAL BEHAV , 80 (2) pp. 205-215. (2003) (2003)
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