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Cortical microstructure in primary progressive aphasia: a multicenter study.
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In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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Protocol for the development of the international population registry for aphasia after stroke (I-PRAISE)
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Ali, M.; Ben Basat, A. L.; Berthier, M.; Johansson, M. B.; Breitenstein, C.; Cadilhac, D. A.; Constantinidou, F.; Cruice, M.; Davila, G.; Gandolfi, M.; Gil, M.; Grima, R.; Godecke, Erin; Jesus, L.; Jiminez, L. M.; Kambanaros, M.; Kukkonen, T.; Laska, A.; Mavis, I.; Mc Menamin, R.; Mendez-Orellana, C.; Obrig, H.; Ostberg, P.; Robson, H.; Sage, K.; Van De Sandt-Koenderman, M.; Sprecht, K.; Visch-Brink, E.; Wehling, E.; Wielaert, S.; Wallace, S. J.; Williams, L. J.; Brady, M. C.
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In: Research outputs 2014 to 2021 (2022)
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Abstract:
Background: We require high-quality information on the current burden, the types of therapy and resources available, methods of delivery, care pathways and long-term outcomes for people with aphasia. Aim: To document and inform international delivery of post-stroke aphasia treatment, to optimise recovery and reintegration of people with aphasia. Methods & Procedures: Multi-centre, prospective, non-randomised, open study, employing blinded outcome assessment, where appropriate, including people with post-stroke aphasia, able to attend for 30 minutes during the initial language assessment, at first contact with a speech and language therapist for assessment of aphasia at participating sites. There is no study-mandated intervention. Assessments will occur at baseline (first contact with a speech and language therapist for aphasia assessment), discharge from Speech and Language Therapy (SLT), 6 and 12-months post-stroke. Our primary outcome is changed from baseline in the Amsterdam Nijmegen Everyday Language Test (ANELT/Scenario Test for participants with severe verbal impairments) at 12-months post-stroke. Secondary outcomes at 6 and 12 months include the Therapy Outcome Measure (TOMS), Subjective Index of Physical and Social Outcome (SIPSO), Aphasia Severity Rating Scale (ASRS), Western Aphasia Battery Aphasia Quotient (WAB-AQ), stroke and aphasia quality of life scale (SAQoL-39), European Quality of Life Scale (EQ-5D), lesion description, General Health Questionnaire (GHQ-12), resource use, and satisfaction with therapy provision and success. We will collect demography, clinical data, and therapy content. Routine neuroimaging and medication administration records will be accessed where possible; imaging will be pseudonymised and transferred to a central reading centre. Data will be collected in a central registry. We will describe demography, stroke and aphasia profiles and therapies available. International individual participant data (IPD) meta-analyses will examine treatment responder rates based on minimal detectable change & clinically important changes from baseline for primary and secondary outcomes at 6 and 12 months. Multivariable meta-analyses will examine associations between demography, therapy, medication use and outcomes, considering service characteristics. Where feasible, costs associated with treatment will be reported. Where available, we will detail brain lesion size and site, and examine correlations with SLT and language outcome at 12 months. Conclusion: International differences in care, resource utilisation and outcomes will highlight avenues for further aphasia research, promote knowledge sharing and optimise aphasia rehabilitation delivery. IPD meta-analyses will enhance and expand understanding, identifying cost-effective and promising approaches to optimise rehabilitation to benefit people with aphasia.
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Keyword:
Aphasia; data collection; Medical Sciences; Medicine and Health Sciences; Neurosciences; outcome assessment; protocol; registry
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URL: https://ro.ecu.edu.au/ecuworkspost2013/11451 https://ro.ecu.edu.au/cgi/viewcontent.cgi?article=12457&context=ecuworkspost2013
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An umbrella review of aphasia intervention description in research: The AsPIRE project
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In: Research outputs 2014 to 2021 (2022)
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Development and diagnostic validation of the Brisbane Evidence-Based Language Test
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In: Research outputs 2014 to 2021 (2022)
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Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: The RELEASE database of aphasia after stroke
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In: Research outputs 2014 to 2021 (2022)
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Inter-rater reliability, intra-rater reliability and internal consistency of the Brisbane Evidence-Based Language Test
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In: Research outputs 2014 to 2021 (2022)
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Developing, monitoring, and reporting of fidelity in aphasia trials: Core recommendations from the collaboration of aphasia trialists (CATs) trials for aphasia panel
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In: Research outputs 2022 to 2026 (2022)
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An aphasia research agenda – a consensus statement from the collaboration of aphasia trialists
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In: Research outputs 2014 to 2021 (2022)
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Investigation of the implementation of a communication enhanced environment model on an acute/slow stream rehabilitation and a rehabilitation ward: A before-and-after pilot study
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In: Research outputs 2014 to 2021 (2022)
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Neuro-Oncology Patients as Human Research Subjects: Ethical Considerations for Cognitive and Behavioral Testing for Research Purposes
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In: Cancers; Volume 14; Issue 3; Pages: 692 (2022)
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A Preliminary Report of Network Electroencephalographic Measures in Primary Progressive Apraxia of Speech and Aphasia
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In: Brain Sciences; Volume 12; Issue 3; Pages: 378 (2022)
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Effect of Lexical-Semantic Cues during Real-Time Sentence Processing in Aphasia
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In: Brain Sciences; Volume 12; Issue 3; Pages: 312 (2022)
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Primary and Secondary Progressive Aphasia in Posterior Cortical Atrophy
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In: Life; Volume 12; Issue 5; Pages: 662 (2022)
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Imaging Clinical Subtypes and Associated Brain Networks in Alzheimer’s Disease
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In: Brain Sciences; Volume 12; Issue 2; Pages: 146 (2022)
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Benefits from Repetitive Transcranial Magnetic Stimulation in Post-Stroke Rehabilitation
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In: Journal of Clinical Medicine; Volume 11; Issue 8; Pages: 2149 (2022)
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Syntactic deficits in language comprehension in individuals with schizophrenia and Broca's aphasia ...
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Syntactic deficits in language comprehension in individuals with schizophrenia and Broca's aphasia ...
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The contribution of white matter pathology, hypoperfusion, lesion load, and stroke recurrence to language deficits following acute subcortical left hemisphere stroke ...
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A 'Mini Linguistic State Examination' to classify primary progressive aphasia. ...
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A 'Mini Linguistic State Examination' to classify primary progressive aphasia. ...
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