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Insights into human genetic variation and population history from 929 diverse genomes
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In: Science (2020)
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Demographic history and genetic adaptation in the Himalayan region inferred from genome-wide SNP genotypes of 49 populations ...
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An Ethnolinguistic and Genetic Perspective on the Origins of the Dravidian-Speaking Brahui in Pakistan
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Wide distribution and altitude correlation of an archaic high-altitude adaptive EPAS1 haplotype in the Himalayas ...
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Ethiopian Genetic Diversity Reveals Linguistic Stratification and Complex Influences on the Ethiopian Gene Pool
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Genetic variation in South Asia: assessing the influences of geography, language and ethnicity for understanding history and disease risk
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Genetic variation in South Asia: assessing the influences of geography, language and ethnicity for understanding history and disease risk
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Abstract:
South Asia is home to more than 1.5 billion humans representing many diverse ethnicities, linguistic and religious groups and representing almost one-quarter of humanity. Modern humans arrived here soon after their departure from Africa ∼50 000–70 000 years before present (YBP) and several subsequent human migrations and invasions, as well as the unique social structure of the region, have helped shape the pattern of genetic diversity currently observed in these populations. Over the last few decades population geneticists and molecular anthropologists have analyzed DNA variation in indigenous populations from this region in order to catalog their genetic relationships and histories. The emphasis is gradually shifting from the study of population origins to high resolution surveys of DNA variation to address issues of population stratification and genetic susceptibility or resistance to diseases in genome-wide association surveys. We present a historical overview of the genetic studies carried out on populations from this region in order to understand the influence of geographic, linguistic and religious factors on population diversity in this region, and discuss future prospects in light of developments in high throughput genotyping and next generation sequencing technologies.
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Keyword:
Technique Review
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URL: http://bfg.oxfordjournals.org/cgi/content/short/elp015v1 https://doi.org/10.1093/bfgp/elp015
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