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1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans
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Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets
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Postema, Merel; Van Rooij, Daan,; Anagnostou, Evdokia; Arango, Celso; Auzias, Guillaume,; Behrmann, Marlene; Filho, Geraldo Busatto; Calderoni, Sara; Calvo, Rosa; Daly, Eileen; Deruelle, Christine; Di Martino, Adriana; Dinstein, Ilan; Duran, Fabio Luis S.; Durston, Sarah; Ecker, Christine; Ehrlich, Stefan; Fair, Damien,; Fedor, Jennifer; Feng, Xin; Fitzgerald, Jackie; Floris, Dorothea; Freitag, Christine,; Gallagher, Louise; Glahn, David,; Gori, Ilaria; Haar, Shlomi; Hoekstra, Liesbeth; Jahanshad, Neda,; Jalbrzikowski, Maria; Janssen, Joost; King, Joseph; Kong, Xiang Zhen; Lazaro, Luisa; Lerch, Jason,; Luna, Beatriz; Martinho, Mauricio; Mcgrath, Jane; Medland, Sarah; Muratori, Filippo; Murphy, Clodagh; Murphy, Declan,; O’Hearn, Kirsten; Oranje, Bob; Parellada, Mara; Puig, Olga; Retico, Alessandra; ROSA, Pedro; Rubia, Katya; Shook, Devon; Taylor, Margot; Tosetti, Michela; Wallace, Gregory; Zhou, Fengfeng; Thompson, Paul; Fisher, Simon; Buitelaar, Jan; Francks, Clyde
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In: ISSN: 2041-1723 ; EISSN: 2041-1723 ; Nature Communications ; https://hal.archives-ouvertes.fr/hal-02365089 ; Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-13005-8⟩ (2019)
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Abstract:
International audience ; Altered structural brain asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have been inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. ASD was significantly associated with alterations of cortical thickness asymmetry in mostly medial frontal, orbitofrontal, cingulate and inferior temporal areas, and also with asymmetry of orbitofrontal surface area. These differences generally involved reduced asymmetry in individuals with ASD compared to controls. Furthermore, putamen volume asymmetry was significantly increased in ASD. The largest case-control effect size was Cohen's d = −0.13, for asymmetry of superior frontal cortical thickness. Most effects did not depend on age, sex, IQ, severity or medication use. Altered lateralized neurodevelopment may therefore be a feature of ASD, affecting widespread brain regions with diverse functions. Large-scale analysis was necessary to quantify subtle alterations of brain structural asymmetry in ASD.
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Keyword:
[SDV]Life Sciences [q-bio]
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URL: https://hal.archives-ouvertes.fr/hal-02365089/file/s41467-019-13005-8.pdf
https://hal.archives-ouvertes.fr/hal-02365089/document
https://doi.org/10.1038/s41467-019-13005-8
https://hal.archives-ouvertes.fr/hal-02365089
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Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
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In: ISSN: 1931-7557 ; EISSN: 1931-7565 ; Brain imaging and behavior (Brain Imaging Behav) ; https://hal.archives-ouvertes.fr/hal-01382787 ; Brain imaging and behavior (Brain Imaging Behav), Secaucus, NJ : Springer, 2017, 11 (5), pp.1497-1514. ⟨10.1007/s11682-016-9629-z⟩ (2017)
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Novel genetic loci associated with hippocampal volume
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In: ISSN: 2041-1723 ; EISSN: 2041-1723 ; Nature Communications ; https://hal.archives-ouvertes.fr/hal-01488337 ; Nature Communications, Nature Publishing Group, 2017, 8, pp.13624. ⟨10.1038/ncomms13624⟩ (2017)
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Novel genetic loci underlying human intracranial volume identified through genome-wide association
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In: ISSN: 1097-6256 ; EISSN: 1546-1726 ; Nature Neuroscience ; https://hal.archives-ouvertes.fr/hal-01382716 ; Nature Neuroscience, Nature Publishing Group, 2016, 19 (12), pp.1569-1582. ⟨10.1038/nn.4398⟩ (2016)
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ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide
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In: ISSN: 1053-8119 ; EISSN: 1095-9572 ; NeuroImage ; https://hal.archives-ouvertes.fr/hal-01380998 ; NeuroImage, Elsevier, 2015, ⟨10.1016/j.neuroimage.2015.11.057⟩ (2015)
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Common genetic variants influence human subcortical brain structures.
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In: ISSN: 0028-0836 ; EISSN: 1476-4679 ; Nature ; https://hal.archives-ouvertes.fr/hal-01196805 ; Nature, Nature Publishing Group, 2015, 520 (7546), pp.224-9. ⟨10.1038/nature14101⟩ (2015)
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The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
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In: ISSN: 1931-7557 ; EISSN: 1931-7565 ; Brain imaging and behavior (Brain Imaging Behav) ; https://hal-pasteur.archives-ouvertes.fr/pasteur-01967166 ; Brain imaging and behavior (Brain Imaging Behav), Secaucus, NJ : Springer, 2014, 8 (2), pp.152-182. ⟨10.1007/s11682-013-9269-5⟩ (2014)
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