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Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network
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Vinarov, Z; Abrahamsson, B; Artursson, P; Batchelor, H; Berben, P; Bernkop-Schnürch, A; Butler, J; Ceulemans, J; Davies, N; Dupont, D; Flaten, GE; Fotaki, N; Griffin, BT; Jannin, V; Keemink, J; Kesisoglou, F; Koziolek, M; Kuentz, M; Mackie, A; Meléndez-Martínez, AJ; McAllister, M; Müllertz, A; O'Driscoll, CM; Parrott, N; Paszkowska, J; Pavek, P; Porter, CJH; Reppas, C; Stillhart, C; Sugano, K; Toader, E; Valentová, K; Vertzoni, M; De Wildt, SN; Wilson, CG; Augustijns, P. - : Elsevier, 2021
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Abstract:
Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.
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URL: https://eprints.whiterose.ac.uk/177211/1/1-s2.0-S0169409X21000351-main.pdf
https://eprints.whiterose.ac.uk/177211/
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General practitioners' perceptions of their communication with Australian Aboriginal patients with acquired neurogenic communication disorders
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Reshaping curricula: Culture and mental health in undergraduate health degrees
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In: Muir-Cochrane, E, O'Kane, D, Mcallister, M, Levett-Jones, T, Gerace, A, (2018). Reshaping curricula: Culture and mental health in undergraduate health degrees. International Journal of Mental Health Nursing, Vol. 27, No. 2, p. 652-661 http://dx.doi.org/10.1111/inm.12350 (2018)
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The stigmatisation of pregnancy: Societal influences on pregnant women’s physical activity behaviour
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In: van Mulken, MRH, McAllister, M, Lowe, JB, (2016). The stigmatisation of pregnancy: Societal influences on pregnant women’s physical activity behaviour. Culture, Health and Sexuality, Vol. 18, No. 8, p. 921-935 http://dx.doi.org/10.1080/13691058.2016.1148199 (2016)
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The stigmatisation of pregnancy: societal influences on pregnant women’s physical activity Behaviour
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Study protocol: missing voices - communication difficulties after stroke and traumatic brain injury in aboriginal Australians
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Taking leave from work: the impact of culture on Japanese female nurses
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Difference, dialogue, dialectics: A study of caring and self harm
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