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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia ...
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
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In: Translational Psychiatry, 9 (1) (2019)
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
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The neuronal migration hypothesis of dyslexia: A critical evaluation 30 years on
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The neuronal migration hypothesis of dyslexia: A critical evaluation 30 years on
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Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
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Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
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Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
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Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
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Genome-wide screening for DNA variants associated with reading and language traits
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment
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Reading and language disorders : the importance of both quantity and quality
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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Associations of HLA alleles with specific language impairment
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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Associations of HLA alleles with specific language impairment
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Nudel, Ron; Simpson, Nuala H; Baird, Gillian; O'Hare, Anne; Conti-Ramsden, Gina; Bolton, Patrick F.; Hennessy, Elizabeth R; Monaco, Anthony P.; Knight, Julian C; Winney, Bruce; Fisher, Simon E.; Newbury, Dianne F.. - 2014
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Abstract:
Human leukocyte antigen (HLA) loci have been implicated in several neurodevelopmental disorders in which language is affected. However, to date, no studies have investigated the possible involvement of HLA loci in specific language impairment (SLI), a disorder that is defined primarily upon unexpected language impairment. We report association analyses of single-nucleotide polymorphisms (SNPs) and HLA types in a cohort of individuals affected by language impairment. We perform quantitative association analyses of three linguistic measures and case-control association analyses using both SNP data and imputed HLA types. Quantitative association analyses of imputed HLA types suggested a role for the HLA-A locus in susceptibility to SLI. HLA-A A1 was associated with a measure of short-term memory (P = 0.004) and A3 with expressive language ability (P = 0.006). Parent-of-origin effects were found between HLA-B B8 and HLA-DQA1*0501 and receptive language. These alleles have a negative correlation with receptive language ability when inherited from the mother (P = 0.021, P = 0.034, respectively) but are positively correlated with the same trait when paternally inherited (P = 0.013, P = 0.029, respectively). Finally, case control analyses using imputed HLA types indicated that the DR10 allele of HLA-DRB1 was more frequent in individuals with SLI than population controls (P = 0.004, relative risk = 2.575), as has been reported for individuals with attention deficit hyperactivity disorder (ADHD). These preliminary data provide an intriguing link to those described by previous studies of other neurodevelopmental disorders and suggest a possible role for HLA loci in language disorders.
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Keyword:
Other systems of medicine
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URL: https://strathprints.strath.ac.uk/47305/1/Nudel_etal_JND_2014_Associations_of_HLA_alleles_with_specific_language_impairment.pdf https://strathprints.strath.ac.uk/47305/ https://doi.org/10.1186/1866-1955-6-1
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort.
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In: ISSN: 1018-4813 ; EISSN: 1476-5438 ; European Journal of Human Genetics ; https://hal.archives-ouvertes.fr/hal-00964958 ; European Journal of Human Genetics, Nature Publishing Group, 2013, epub ahead of print. ⟨10.1038/ejhg.2013.199⟩ (2013)
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