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1
The neural substrates of improved phonological processing following successful treatment in a case of phonological alexia and agraphia
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2
The nature and treatment of phonological text agraphia
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3
Neural Substrates of Sublexical Processing for Spelling
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4
Processing deficits for familiar and novel faces in patients with left posterior fusiform lesions
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5
Positive Effects of Language Treatment for the Logopenic Variant of Primary Progressive Aphasia
Abstract: Despite considerable recent progress in understanding the underlying neurobiology of primary progressive aphasia (PPA) syndromes, relatively little attention has been directed toward the examination of behavioral interventions that may lessen the pervasive communication problems associated with PPA. In this study, we report on an individual with a behavioral profile and cortical atrophy pattern consistent with the logopenic variant of PPA. At roughly two-and-a-half years post onset, his marked lexical retrieval impairment prompted administration of a semantically based intervention to improve word retrieval. The treatment was designed to improve self-directed efforts to engage the participant’s relatively preserved semantic system in order to facilitate word retrieval. His positive response to an intensive (2-week) dose of behavioral treatment was associated with improved lexical retrieval of items within trained categories, and generalized improvement for naming of untrained items that lasted over a 6-month follow-up interval. These findings support the potential value of intensive training to achieve self-directed strategic compensation for lexical retrieval difficulties in logopenic PPA. Additional insight was gained regarding the neural regions that supported improved performance by the administration of a functional magnetic resonance imaging protocol before and after treatment. In the context of a picture-naming task, post-treatment fMRI showed increased activation of left dorsolateral prefrontal regions that have been implicated in functional imaging studies of generative naming in healthy individuals. The increased activation in these frontal regions that were not significantly atrophic in our patient (as determined by voxel-based morphometry) is consistent with the notion that neural plasticity can support compensation for specific language loss, even in the context of progressive neuronal degeneration.
Keyword: Article
URL: http://www.ncbi.nlm.nih.gov/pubmed/21710364
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208072
https://doi.org/10.1007/s12031-011-9579-2
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6
Written language impairments in primary progressive aphasia: A reflection of damage to central semantic and phonological processes
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7
Lexical Retrieval Treatment for Primary Progressive Aphasia
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8
A Treatment Sequence for Phonological Alexia/Agraphia
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9
Initial validity and reliability of the SCCAN: using tailored testing to assess adult cognition and communication
In: Journal of speech, language, and hearing research. - Rockville, Md. : American Speech-Language-Hearing Association 51 (2008) 1, 49-69
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10
A novel method for examining response to spelling treatment
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 22 (2008) 7-8, 707-717
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OLC Linguistik
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11
Treatment for lexical retrieval in progressive aphasia
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 22 (2008) 7-8, 826-838
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OLC Linguistik
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12
Lexical retrieval and semantic knowledge in patients with left inferior temporal lobe lesions
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 22 (2008) 3, 281-304
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OLC Linguistik
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13
Treatment for Anomia in Semantic Dementia
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14
Treatment for lexical retrieval in progressive aphasia
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15
Phonological Dyslexia and Dysgraphia: Cognitive Mechanisms and Neural Substrates
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16
Lexical retrieval and semantic knowledge in patients with left inferior temporal lobe lesions
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17
The role of left perisylvian cortical regions in spelling
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 100 (2007) 1, 44-52
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18
The role of left perisylvian cortical regions in spelling ☆
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19
Anomia in patients with left inferior temporal lobe lesions
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 18 (2004) 5-7, 543-554
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20
Does the representation of time depend on the cerebellum? : Effect of cerebellar stroke
In: Brain. - Oxford : Oxford Univ. Press 127 (2004) 3, 561-574
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