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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 1 of 1 1 COL1A2 (Type 1 Collagen) polymorphism in the Colorado Indians of Ecuador Babalini, C; Tarsi, T; Martínez-Labarga, C; Scano, G; Pepe, G; De Stefano, GF; Rickards, O. - : Informa Healthcare, 2005 Abstract: Background: EcoRI, MspI and RsaI restriction fragment length polymorphisms (RFLPs) of the COL1A2 (type I collagen) gene are proving to be extremely informative markers for describing human populations; therefore they hold considerable potential for anthropogenetic research. Aim: The objective of this study was to characterize at the DNA level the Colorado Indians from Ecuador, for whom only blood group frequency information is available, and to investigate their relationships with the Cayapa—another Ecuadoran Native American group belonging to the same linguistic affiliation—and other world populations. Subjects and methods: Colorado Indians (n¼80) were analysed for the three anthropologically informative RFLPs of the COL1A2 gene. To better define the genetic relationship between this group and other populations, principal component analysis (PCA) was performed and genetic distances were estimated. Population genetic structure was tested through analysis of molecular variance (AMOVA) by comparing haplotype frequencies. Results: COL1A2 allele and haplotype frequencies showed a certain degree of heterogeneity between the two Chibchan populations of Ecuador. The AMOVA test detected a significant level of differentiation (Fst¼0.034, p¼0.0049) between Colorado and Cayapa Indians. PC and genetic distance analyses showed a clear-cut separation between African and non-African populations; within the latter, the two Native American groups were differentiated from each other. Conclusions: The present findings suggest the presence of a low level of genetic relatedness between the Colorado and the Cayapa, despite their supposed common ethnogenesis. This confirms what has been inferred from other genetic data about the high degree of heterogeneity among Native Americans, even within the same linguistic branch, thus supporting the existence of genetic sub-structure within the central and southern American populations. Keyword: COL1A2; Ecuadoran Colorado Indians; RFLPs; Settore BIO/08 - Antropologia URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-34447341690&partnerID=40&md5=da3ef19a8b36ee98f2d739aea667b2a6 http://hdl.handle.net/2108/37936 https://doi.org/10.1080/03014460701362356 BASE Hide details

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